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Polyphenolics from Syzygium brachythyrsum Inhibits Oxidized Low-Density Lipoprotein-Induced Macrophage-Derived Foam Cell Formation and Inflammation
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- Chen, Xue-Lian (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Liang, Pu-Lin (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Gong, Ming-Jiong (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Xu, Ya (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Zhang, Liang (författare)
- Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China.
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- Qiu, Xiao-Hui (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Zhang, Jing (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Huang, Zhi-Hai (författare)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Xu, Wen (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China. (creator_code:org_t)
- 2022-11-07
- 2022
- Engelska.
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Ingår i: Foods. - : MDPI. - 2304-8158. ; 11:21
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Evidence suggests that the immunomodulatory property of polyphenols may also contribute to the reduction of cardiovascular risk. In the present study, we investigated the polyphenol extraction (PE) from Syzygium brachythyrsum, a functional food resource in south China, regarding the protective effect on inhibiting foam cell formation and the underlying molecular mechanism based on an ox-LDL-induced RAW264.7 macrophage model. The results of Oil Red O staining, Dil-ox-LDL fluorescent staining, and cholesterol efflux experiments showed that PE, and its two phenolics brachythol B (BB) and ethyl gallate (EG), significantly inhibited the foam cell formation, which may be associated with reducing the expression of SR-A1 and CD36 while increasing expression of SR-B1, ABCG1, and PPAR gamma. In addition, BB and EG also reduce the inflammatory response by down-regulating the expression of NF-kappa B and MAPK signal pathway proteins, thereby inhibiting the expression of inflammatory factors. Altogether, PE and its two components BB and EG attenuated foam cell formation and macrophage inflammation response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Syzygium brachythyrsum
- polyphenols
- foam cell
- ox-LDL
- cholesterol
- inflammation
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- ref (ämneskategori)
- art (ämneskategori)
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