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Urine Galectin-3 bi...
Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus
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- Faustini, Francesca (författare)
- Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, 59562Karolinska Institute, Stockholm, Sweden.
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- Idborg, Helena (författare)
- Karolinska Institutet
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- Fuzzi, Enrico (författare)
- Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, 59562Karolinska Institute, Stockholm, Sweden.
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Lie, Wen-Rong (författare)
- EMD Millipore Corporation, St Louis, MO, USA.
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- Pötzsch, Sven (författare)
- 2792Merck KGaA, Darmstadt, Germany.
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- Okitsu, Shinji L (författare)
- 189697EMD Serono Research and Development Institute, Billerica, MA, USA.
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet
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- Gunnarsson, Iva (författare)
- Karolinska Institutet
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Karolinska Institutet Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, 59562Karolinska Institute, Stockholm, Sweden (creator_code:org_t)
- 2022-12-12
- 2023
- Engelska.
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Ingår i: Lupus. - : Sage Publications. - 0961-2033 .- 1477-0962. ; 32:2, s. 252-262
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Lupus nephritis (LN) is a major and severe organ involvement in systemic lupus erythematosus (SLE), whose diagnosis and treatment necessitate to perform kidney biopsy, which is an invasive procedure. Non-invasive urine biomarkers are an active area of investigation to support LN diagnosis and management.OBJECTIVE: To investigate the role of urinary galectin-3 binding protein (u-Gal-3BP) as a candidate biomarker of renal disease in biopsy proven LN.PATIENTS AND METHODS: Levels of u-Gal-3BP were investigated in a cross-sectional fashion by ELISA in 270 subjects: 86 LN patients, 63 active SLE patients with no kidney involvement, 73 SLE patients with inactive disease and 48 age and sex-matched population-based controls (PBC). Moreover, urine samples were analysed separately by ELISA for additional markers of kidney pathology: neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), kidney injury molecule-1 (KIM-1) and galectin-3 (Gal-3). The concentrations of all studied molecules were normalized to urine creatinine levels. In 10 patients, post-treatment levels of the biomarkers were measured.RESULTS: Normalized u-Gal-3BP levels were higher in LN patients compared to the other groups (p < .0001). Comparing different LN classes, u-Gal-3BP levels were higher among patients with proliferative (class III/IV) and membranous (class V) as compared to mesangial (class II) forms (p = .04). In proliferative forms, u-Gal-3BP levels correlated with the activity index in renal biopsies (r = 0.42, p = .004). Moreover, in a subset of 10 patients with repeated kidney biopsy and urine sampling before and after induction treatment, a significant decrease of u-Gal-3BP was observed (p = .03). Among the other markers, KIM-1 was also able to discriminate LN from the other groups, while NGAL, OPN and Gal-3 could not in this cohort.CONCLUSION: Given its ability to discriminate LN patients from active non-renal and inactive SLE patients, the observed correlation with the activity index in renal biopsies, and its levels declining following treatment, u-Gal-3BP shows promise as a non-invasive urinary biomarker to help detecting and to monitor renal involvement in SLE patients and should be validated in larger cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Galectin-3 binding protein
- Systemic lupus erythematous
- lupus nephritis
- urinarybiomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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