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Fabrication of PEGy...
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Zaman, MuhammadUniv Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.
(författare)
Fabrication of PEGylated Chitosan Nanoparticles Containing Tenofovir Alafenamide : Synthesis and Characterization
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-12-01
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MDPI,2022
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-493016
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-493016URI
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https://doi.org/10.3390/molecules27238401DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Tenofovir alafenamide (TAF) is an antiretroviral (ARV) drug that is used for the management and prevention of human immunodeficiency virus (HIV). The clinical availability of ARV delivery systems that provide long-lasting protection against HIV transmission is lacking. There is a dire need to formulate nanocarrier systems that can help in revolutionizing the way to fight against HIV/AIDS. Here, we aimed to synthesize a polymer using chitosan and polyethylene glycol (PEG) by the PEGylation of chitosan at the hydroxyl group. After successful modification and confirmation by FTIR, XRD, and SEM, TAF-loaded PEGylated chitosan nanoparticles were prepared and analyzed for their particle size, zeta potential, morphology, crystallinity, chemical interactions, entrapment efficacy, drug loading, in vitro drug release, and release kinetic modeling. The fabricated nanoparticles were found to be in a nanosized range (219.6 nm), with similar to 90% entrapment efficacy, similar to 14% drug loading, and a spherical uniform distribution. The FTIR analysis confirmed the successful synthesis of PEGylated chitosan and nanoparticles. The in vitro analysis showed similar to 60% of the drug was released from the PEGylated polymeric reservoir system within 48 h at pH 7.4. The drug release kinetics were depicted by the Korsmeyer-Peppas release model with thermodynamically nonspontaneous drug release. Conclusively, PEGylated chitosan has the potential to deliver TAF from a nanocarrier system, and in the future, cytotoxicity and in vivo studies can be performed to further authenticate the synthesized polymer.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hammad Butt, MuhammadUppsala universitet,Institutionen för läkemedelskemi
(författare)
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Siddique, WaqarUniv South Asia USA, Dept Pharm, Lahore 54000, Pakistan.;Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.
(författare)
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Iqbal, Muhammad OmerOcean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycoscience & Glycoengn, Qingdao 266003, Peoples R China.;Royal Inst Med Sci, Multan 59300, Pakistan.
(författare)
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Nisar, NaveedInst Res & Adv Studies Pharm IRASP, Multan 59300, Pakistan.;Bahauddin Zakariya Univ Multan, Fac Pharm, Multan 59300, Pakistan.
(författare)
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Mumtaz, AsmaMultan Med & Dent Coll, Multan 59300, Pakistan.
(författare)
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Nazeer, Hafiza YusraBahauddin Zakariya Univ Multan, Fac Pharm, Multan 59300, Pakistan.
(författare)
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Alshammari, AbdulrahmanKing Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Post Box 2455, Riyadh 11451, Saudi Arabia.
(författare)
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Riaz, Muhammad ShahidUniv Valencia, Fac Pharm, Food Sci Toxicol & Forens Med Dept, Nutr & Food Sci Area,Prevent Med & Publ Hlth, Avda Vicent Andres Estelles S-N, Valencia 46100, Spain.
(författare)
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Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.Institutionen för läkemedelskemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecules: MDPI27:231431-51571420-3049
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