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Sökning: onr:"swepub:oai:DiVA.org:uu-497029" > Validating the risk...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004250naa a2200505 4500
001oai:DiVA.org:uu-497029
003SwePub
008230223s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4970292 URI
0247 a https://doi.org/10.1093/bjs/znad3662 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Annebäck, Matildau Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)matan693
2451 0a Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort :b plea for improved follow-up
264 1b Oxford University Press,c 2024
338 a electronic2 rdacarrier
500 a Title in the list of papers of Matilda Annebäck's thesis: Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: a plea for improved follow-up
520 a BackgroundA previous nationwide study from Sweden showed that the rate of permanent hypoparathyroidism is high and under-rated in the Swedish Quality Register. This retrospective population-based study aimed to validate the rate and diagnosis of permanent hypoparathyroidism found in the previous study. A secondary aim was to assess the relationship between the rate of low parathyroid hormone (PTH) levels within 24 h after surgery and the rate of permanent hypoparathyroidism.MethodsAll patients who underwent total thyroidectomy from 2005 to 2015 in a region of Sweden were included. Data were retrieved from local health records, the National Patient Registry, the Swedish Prescribed Drug Registry, and the Swedish Quality Register. A strict definition of permanent hypoparathyroidism was used, including biochemical data and attempts to stop the treatment.ResultsA total of 1636 patients were included. Altogether, 143 patients (8.7 per cent) developed permanent hypoparathyroidism. Of these, 102 (6.2 per cent) had definitive permanent hypoparathyroidism, whereas 41 (2.5 per cent) had possible permanent hypoparathyroidism, because attempts to stop the treatment were lacking (28) or patients were lost to follow-up (13). The agreement between the Swedish Quality Register and the chart review was 29.3 per cent. A proportion of 23.2 per cent with a PTH level below the reference value corresponded to a 6.7 per cent rate of permanent hypoparathyroidism.ConclusionThe risk of permanent hypoparathyroidism after total thyroidectomy is high. Some patients are overtreated because attempts to stop the treatment are lacking. Quality registers might underestimate the risk of permanent hypoparathyroidism. Approximately one-quarter of all patients with low PTH levels immediately after surgery developed permanent hypoparathyroidism.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Thyroidectomy
653 a hypoparathyroidism
653 a parathyroid hormone
653 a quality register
653 a Surgery
653 a Kirurgi
7001 a Osterman, Carolina4 aut
7001 a Arlebrink, Jesper4 aut
7001 a Mellerstedt, Simon4 aut
7001 a Papathanasakis, Nicolas4 aut
7001 a Wallin, Göran4 aut
7001 a Hessman, Ola4 aut
7001 a Annerbo, Maria4 aut
7001 a Norlén, Olovu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)olono376
7102 a Uppsala universitetb Endokrinkirurgi4 org
7730 t British Journal of Surgeryd : Oxford University Pressg 111:1q 111:1x 0007-1323x 1365-2168
8564 u https://doi.org/10.1093/bjs/znad366y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1738819/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497029
8564 8u https://doi.org/10.1093/bjs/znad366

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