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Sökning: onr:"swepub:oai:DiVA.org:uu-498343" > Plasma expansion an...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004360nam a2200373 4500
001oai:DiVA.org:uu-498343
003SwePub
008230314| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4983432 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Luther, Tomasu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)tomek221
2451 0a Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
338 a print2 rdacarrier
520 a Introduction: A decrease in renal perfusion during acute kidney injury (AKI) due to critical COVID-19 have previously been demonstrated. The objective of this study was to compare the effects of plasma expansion with a standardized fluid bolus on renal perfusion in critically ill patients with AKI compared to similar patients without AKI.  Methods: A case control study design was used to investigate group differences before and after a standardized intervention. ICU-treated COVID-19 patients without underlying kidney disease were assigned to two groups based on KDIGO Creatinine criteria for AKI. Renal perfusion was assessed by magnetic resonance imaging using phase contrast and arterial spin labeling before and directly after plasma expansion with 7.5ml/kg Ringer’s Acetate (Baxter). Mean arterial pressure (MAP) was recorded before plasma infusion and compared with maximum value after. Data was analyzed with a mixed model repeated measures ANOVA for all kidneys using a random effect to account for research subjects. Results: Nine patients with AKI and eight without were included in the study. The hemodynamic response to plasma expansion was similar in both groups with increases in MAP by 18 mmHg (CI 8-28) and 20 mmHg (CI 10-31) in patients with and without AKI respectively. Total renal perfusion and cortical perfusion was not significantly changed by plasma expansion in either group. There were however there was a reduction of medullary perfusion in patients without AKI from 55 (CI 39-79) to 34 (CI 24-48) ml/min/100g (P = 0.0027).Conclusion: Plasma expansion with a standardized fluid bolus did not increase renal perfusion in critically ill patients with COVID-19.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
653 a Anestesiologi och intensivvård
653 a Anaesthesiology and Intensive Care
7001 a Eckerbom, Per,d 1974-u Uppsala universitet,Radiologi4 aut0 (Swepub:uu)perec430
7001 a Cox, Eleanoru Sir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Not-tingham, Nottingham, UK and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK4 aut
7001 a Lipcsey, Miklósu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)milip123
7001 a Bülow Anderberg, Sarau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)sarbu486
7001 a Hultström, Michael,d 1978-u Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi4 aut0 (Swepub:uu)mihul498
7001 a Weis, Jan,d 1956-u Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)janweis
7001 a Palm, Fredrik,d 1973-u Uppsala universitet,Integrativ Fysiologi4 aut0 (Swepub:uu)fredpalm
7001 a Francis, Susanu Sir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Not-tingham, Nottingham, UK and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK4 aut
7001 a Liss, Per,d 1960-u Uppsala universitet,Radiologi,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)perliss
7001 a Frithiof, Robertu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)robfr118
7102 a Uppsala universitetb Anestesiologi och intensivvård4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498343

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