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Striatal dopamine t...
Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [11C]PE2I, [18F]FE-PE2I and [11C]raclopride PET in healthy individuals
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- Jonasson, My (författare)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden; Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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- Frick, Andreas, Docent (författare)
- Uppsala universitet,Psykiatri,Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden
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- Fazio, Patrik (författare)
- Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
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- Hjorth, Olof (författare)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Danfors, Torsten, 1964- (författare)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden; Medical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Radiofysik
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- Appel, Lieuwe (författare)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden; Medical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Varrone, Andrea (författare)
- Karolinska Institutet
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Medical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden,Department of Surgical Sciences, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden; Medical Physics, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Sage Publications, 2023
- 2023
- Engelska.
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Ingår i: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 43:7, s. 1206-1215
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The aim of this retrospective study was to investigate relationships between relative cerebral blood flow and striatal dopamine transporter and dopamine D2/3 availability in healthy subjects. The data comprised dynamic PET scans with two dopamine transporter tracers [11C]PE2I (n = 20) and [18F]FE-PE2I (n = 20) and the D2/3 tracer [11C]raclopride (n = 18). Subjects with a [11C]PE2I scan also underwent a dynamic scan with the serotonin transporter tracer [11C]DASB. Binding potential (BPND) and relative tracer delivery (R1) values were calculated on regional and voxel-level. Striatal R1 and BPND values were correlated, using either an MRI-based volume of interest (VOI) or an isocontour VOI based on the parametric BPND image. An inter-tracer comparison between [11C]PE2I BPND and [11C]DASB R1 was done on a VOI-level and simulations were performed to investigate whether the constraints of the modeling could cause correlation of the parameters. A positive association was found between BPND and R1 for all three dopamine tracers. A similar correlation was found for the inter-tracer correlation between [11C]PE2I BPND and [11C]DASB R1. Simulations showed that this relationship was not caused by cross-correlation between parameters in the kinetic model. In conclusion, these results suggest an association between resting-state striatal dopamine function and relative blood flow in healthy subjects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Nyckelord
- Binding potential
- dopamine system
- kinetic modelling
- PET
- relative cerebral blood flow
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Jonasson, My
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Frick, Andreas, ...
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Fazio, Patrik
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Hjorth, Olof
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Danfors, Torsten ...
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Axelsson, Jan, 1 ...
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visa fler...
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Appel, Lieuwe
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Furmark, Tomas
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Varrone, Andrea
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Lubberink, Mark
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk bildbe ...
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Journal of Cereb ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Karolinska Institutet