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Emotion-induced bra...
Emotion-induced brain activation across the menstrual cycle in individuals with premenstrual dysphoric disorder and associations to serum levels of progesterone-derived neurosteroids
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- Stiernman, Louise (författare)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.
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- Dubol, Manon (författare)
- Uppsala universitet,Comasco: Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab,Neuropsykofarmakologi,Department of Women's and Children's Health, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Farmakologi,Centrum för klinisk forskning, Västerås,Neuropsykofarmakologi,Obstetrik & gynekologi,Reproduktiv hälsa,Science for Life Laboratory, SciLifeLab,Comasco: Neuropsykofarmakologi,Department of Women's and Children's Health, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
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- Boraxbekk, Carl-Johan, 1980- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark,Umeå Univ, Dept Radiat Sci, Diagnost Radiol, Umeå, Sweden.;Univ Copenhagen, Inst Clin Med, Fac Med & Hlth Sci, Copenhagen, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Danish Res Ctr Magnet Resonance DRCMR, Ctr Funct & Diagnost Imaging & Res, Copenhagen, Denmark.;Umeå Univ, Umeå Ctr Funct Brain Imaging UFBI, Umeå, Sweden.;Copenhagen Univ Hosp Bispebjerg, Inst Sports Med Copenhagen ISMC, Copenhagen, Denmark.;Copenhagen Univ Hosp Bispebjerg, Dept Neurol, Copenhagen, Denmark.
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- Johansson, Inga-Maj (författare)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.
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- Bixo, Marie (författare)
- Umeå universitet,Obstetrik och gynekologi,Umeå Univ, Dept Clin Sci, Umeå, Sweden.
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13:1
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Premenstrual dysphoric disorder (PMDD) is a debilitating disorder characterized by severe mood symptoms in the luteal phase of the menstrual cycle. PMDD symptoms are hypothesized to be linked to an altered sensitivity to normal luteal phase levels of allopregnanolone (ALLO), a GABA(A)-modulating progesterone metabolite. Moreover, the endogenous 3 beta-epimer of ALLO, isoallopregnanolone (ISO), has been shown to alleviate PMDD symptoms through its selective and dose-dependent antagonism of the ALLO effect. There is preliminary evidence showing altered recruitment of brain regions during emotion processing in PMDD, but whether this is associated to serum levels of ALLO, ISO or their relative concentration is unknown. In the present study, subjects with PMDD and asymptomatic controls underwent functional magnetic resonance imaging (fMRI) in the mid-follicular and the late-luteal phase of the menstrual cycle. Brain responses to emotional stimuli were investigated and related to serum levels of ovarian steroids, the neurosteroids ALLO, ISO, and their ratio ISO/ALLO. Participants with PMDD exhibited greater activity in brain regions which are part of emotion-processing networks during the late-luteal phase of the menstrual cycle. Furthermore, activity in key regions of emotion processing networks - the parahippocampal gyrus and amygdala - was differentially associated to the ratio of ISO/ALLO levels in PMDD subjects and controls. Specifically, a positive relationship between ISO/ALLO levels and brain activity was found in PMDD subjects, while the opposite was observed in controls. In conclusion, individuals with PMDD show altered emotion-induced brain responses in the late-luteal phase of the menstrual cycle which may be related to an abnormal response to physiological levels of GABA(A)-active neurosteroids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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