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Coupling microchip ...
Coupling microchip pressure regulators with chipHPLC as a step toward fully portable analysis system
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- Svensson, Karolina, 1993- (författare)
- Uppsala universitet,Mikrosystemteknik,Centre of Natural Hazards and Disaster Science.
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- Weise, Chris (författare)
- Univ Leipzig, Inst Analyt Chem, Linnestr 3, D-04103 Leipzig, Germany.
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- Westphal, Hannes (författare)
- Univ Leipzig, Inst Analyt Chem, Linnestr 3, D-04103 Leipzig, Germany.
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- Södergren, Simon, 1992- (författare)
- Uppsala universitet,Mikrosystemteknik,Centre of Natural Hazards and Disaster Science.
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- Belder, Detlev (författare)
- Univ Leipzig, Inst Analyt Chem, Linnestr 3, D-04103 Leipzig, Germany.
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- Hjort, Klas, 1964- (författare)
- Uppsala universitet,Mikrosystemteknik,Centre of Natural Hazards and Disaster Science.
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 385
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Herein the coupling of a miniaturized, nanoliter scaled, pressure regulator (chipPR), and a chipHPLC device is introduced. The active temperature based flow control of the chipPR is able to generate rapid pressure changes and therefore enables on-chip pinched injection and flow gradients with reduced instrumental effort and minimal dead volumes. The functionality of the chipPR empowered chipHLPC device was demonstrated with high-speed HPLC-separations applying fluorescence and electrospray mass spectrometry (ESI-MS) detection. The system shows excellent long-term stability of chromatography integrity (retention times with RSD of 0.44-0.91%) due to the integration of a PID feedback regulation. This first chip-based HPLC device equipped with chipPRs enables precise flow control with significantly reduced technical effort compared to the state-of-the-art.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Annan elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Other Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Lab-on-a-chip
- ChipHPLC
- Thermal actuation
- Microfluidics
- Pressure regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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