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Rapid adaptations o...
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Leenheer, DaniëlUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Univ Tsukuba, Sch Integrat & Global Majors, PhD Program Human Biol, Tsukuba, Japan
(författare)
Rapid adaptations of Legionella pneumophila to the human host
- Artikel/kapitelEngelska2023
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Microbiology Society,2023
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LIBRIS-ID:oai:DiVA.org:uu-502640
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502640URI
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https://doi.org/10.1099/mgen.0.000958DOI
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Språk:engelska
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Sammanfattning på:engelska
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Legionella pneumophila are host-adapted bacteria that infect and reproduce primarily in amoeboid protists. Using similar infection mechanisms, they infect human macrophages, and cause Legionnaires’ disease, an atypical pneumonia, and the milder Pontiac fever. We hypothesized that, despite the similarities in infection mechanisms, the hosts are different enough that there exist high-selective value mutations that would dramatically increase the fitness of Legionella inside the human host. By comparing a large number of isolates from independent infections, we identified two genes, mutated in three unrelated patients, despite the short duration of the incubation period (2–14 days). One is a gene coding for an outer membrane protein (OMP) belonging to the OmpP1/FadL family. The other is a gene coding for an EAL-domain-containing protein involved in cyclic-di-GMP regulation, which in turn modulates flagellar activity. The clinical strain, carrying the mutated EAL-domain-containing homologue, grows faster in macrophages than the wild-type strain, and thus appears to be better adapted to the human host. As human-to-human transmission is very rare, fixation of these mutations into the population and spread into the environment is unlikely. Therefore, parallel evolution – here mutations in the same genes observed in independent human infections – could point to adaptations to the accidental human host. These results suggest that despite the ability of L. pneumophila to infect, replicate in and exit from macrophages, its human-specific adaptations are unlikely to be fixed in the population.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Moreno, Anaísa B.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)animo450
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Paranjape, KiranUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)kirpa873
(författare)
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Murray, SusanUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)susmu240
(författare)
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Jarraud, SophieHosp Civils Lyon, Inst Infect Agents, French Natl Reference Ctr Legionella, Lyon, France.;Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, Legionella Pathogenesis Team, CIRI,CNRS,UMR5308,ENS Lyon, Lyon, France.
(författare)
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Ginevra, ChristopheHosp Civils Lyon, Inst Infect Agents, French Natl Reference Ctr Legionella, Lyon, France.;Univ Claude Bernard Lyon 1, Ctr Int Rech Infectiol, Legionella Pathogenesis Team, CIRI,CNRS,UMR5308,ENS Lyon, Lyon, France.
(författare)
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Guy, Lionel,PhD, Docent,1980-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)liogu139
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
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Ingår i:Microbial Genomics: Microbiology Society9:32057-5858
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