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Reducing carbon foo...
Reducing carbon footprint by switching to reusable soft-mist inhalers
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Platz, Jaime Hernando (författare)
- Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
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- Soulard, Stephane (författare)
- Boehringer Ingelheim bv, Amsterdam, Netherlands.
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- Langham, Sue (författare)
- Maverex Ltd, Newcastle Upon Tyne, Tyne & Wear, England.
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- Nicholson, Lindsay (författare)
- Maverex Ltd, Newcastle Upon Tyne, Tyne & Wear, England.
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- Hartgers-Gubbels, Elisabeth Sophia (författare)
- Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
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(creator_code:org_t)
- 2023-03-16
- 2023
- Engelska.
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Ingår i: ERJ Open Research. - : European Respiratory Society (ERS). - 2312-0541. ; 9:3
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: Inhalation therapy is the cornerstone of COPD, together with non-pharmacological treatments. Long-acting muscarinic antagonists (LAMAs), alone or in combination with long-acting beta-agonists (LABAs), are commonly used. Pressurised metered-dose inhalers (pMDIs), dry powder inhalers (DPIs) and soft-mist inhalers (SMIs) are used, each with different carbon footprints. This study aimed to assess the carbon footprint of hypothetically replacing LAMA or LAMA/LABA inhalers with an SMI, Respimat Reusable, within the same therapeutic class.Methods: An environmental impact model was established to assess the change in carbon footprint of replacing pMDIs/DPIs with Respimat Reusable within the same therapeutic class (LAMA or LAMA/LABA) across 12 European countries and the USA over 5 years. Inhaler use for country and diseasespecific populations was derived from international prescribing data and the associated carbon footprint (CO2 equivalents (CO(2)e)) was identified from published sources.Results: Over 5 years and across all countries, replacing LAMA inhalers with Spiriva Respimat Reusable reduced CO(2)e emissions by 13.3-50.9%, saving 93-6228 tonnes of CO(2)e in the different countries studied. Replacing LAMA/LABA inhalers with Spiolto Respimat Reusable reduced CO(2)e emissions by 9.5-92.6%, saving 31-50 843 tonnes of CO(2)e. In scenario analyses, which included total replacement of DPIs/pMDIs, consistent CO(2)e savings were estimated. Sensitivity analyses showed that results were sensitive to changes in several parameters including varying assumptions around reusability of inhalers and potential CO(2)e impact.Conclusion: Replacement of pMDIs and DPIs with Respimat Reusable within the same therapeutic class would result in substantial reductions in CO(2)e emissions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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