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Cross-reactive EBNA...
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Thomas, Olivia G.Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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American Association for the Advancement of Science (AAAS),2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-506588
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506588URI
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https://doi.org/10.1126/sciadv.adg3032DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152861661URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which and Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between Epstein-Barr nuclear antigen 1 (EBNA1) and alpha-crystallin B (CRYAB), we examined antibody reactivity to EBNA1 and CRYAB peptide libraries in 713 persons with MS (pwMS) and 722 matched controls (Con). Antibody response to CRYAB amino acids 7 to 16 was associated with MS (OR = 2.0), and combination of high EBNA1 responses with CRYAB positivity markedly in-creased disease risk (OR = 9.0). Blocking experiments revealed antibody cross-reactivity between the homolo-gous EBNA1 and CRYAB epitopes. Evidence for T cell cross-reactivity was obtained in mice between EBNA1 and CRYAB, and increased CRYAB and EBNA1 CD4+ T cell responses were detected in natalizumab-treated pwMS. This study provides evidence for antibody cross-reactivity between EBNA1 and CRYAB and points to a similar cross-reactivity in T cells, further demonstrating the role of EBV adaptive immune responses in MS development.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bronge, MattiasKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Tengvall, Katarina,1980-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.(Swepub:uu)katst103
(författare)
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Akpinar, BirceKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Nilsson, Ola B.Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Holmgren, ErikKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Hessa, TaraKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Gafvelin, GuroKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Khademi, MohsenKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.
(författare)
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Alfredsson, LarsKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.
(författare)
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Martin, RolandKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.;Univ Zurich, Inst Expt Immunol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
(författare)
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Guerreiro-Cacais, Andre OrtliebKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.
(författare)
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Grönlund, HansKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(författare)
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Olsson, TomasKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.
(författare)
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Kockum, IngridKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.
(författare)
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Karolinska InstitutetKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Science Advances: American Association for the Advancement of Science (AAAS)9:202375-2548
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Till lärosätets databas
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Thomas, Olivia G ...
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Bronge, Mattias
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Tengvall, Katari ...
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Akpinar, Birce
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Nilsson, Ola B.
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Holmgren, Erik
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visa fler...
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Hessa, Tara
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Gafvelin, Guro
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Khademi, Mohsen
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Alfredsson, Lars
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Martin, Roland
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Guerreiro-Cacais ...
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Grönlund, Hans
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Olsson, Tomas
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Kockum, Ingrid
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visa färre...
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