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Current status of c...
Current status of contemporary diagnostic radiotracers in the management of breast cancer : first steps toward theranostic applications
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- Altena, Renske (författare)
- Karolinska Institutet
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- Tzortzakakis, Antonios (författare)
- Karolinska Institutet
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- Buren, Siri Af (författare)
- Karolinska Institutet
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- Tran, Thuy A. (författare)
- Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Med Unit Breast Endocrine Tumors & Sarcoma, Theme Canc, Solna, Sweden.;Karolinska Univ Hosp, Dept Radiopharm, Solna, Sweden.
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- Frejd, Fredrik Y. (författare)
- Uppsala universitet,Cancerprecisionsmedicin,Affibody AB, Solna, Sweden.
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- Bergh, Jonas (författare)
- Karolinska Institutet
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- Axelsson, Rimma (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Karolinska Comprehens Canc Ctr, Med Unit Breast Endocrine Tumors & Sarcoma, Theme Canc, Solna, Sweden;Karolinska Univ Hosp, Dept Radiopharm, Solna, Sweden. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: EJNMMI Research. - : Springer Nature. - 2191-219X. ; 13:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundExpanding therapeutic possibilities have improved disease-related prospects for breast cancer patients. Pathological analysis on a tumor biopsy is the current reference standard biomarker used to select for treatment with targeted anticancer drugs. This method has, however, several limitations, related to intra- and intertumoral as well as spatial heterogeneity in receptor expression as well as the need to perform invasive procedures that are not always technically feasible.Main bodyIn this narrative review, we focus on the current role of molecular imaging with contemporary radiotracers for positron emission tomography (PET) in breast cancer. We provide an overview of diagnostic radiotracers that represent treatment targets, such as programmed death ligand 1, human epidermal growth factor receptor 2, polyadenosine diphosphate-ribose polymerase and estrogen receptor, and discuss developments in therapeutic radionuclides for breast cancer management.ConclusionImaging of treatment targets with PET tracers may provide a more reliable precision medicine tool to find the right treatment for the right patient at the right time. In addition to visualization of the target of treatment, theranostic trials with alpha- or beta-emitting isotopes provide a future treatment option for patients with metastatic breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Molecular imaging
- Predictive biomarker
- Breast cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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