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Sökning: onr:"swepub:oai:DiVA.org:uu-507451" > Equine in vivo meta...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03627naa a2200457 4500 | |
| 001 | oai:DiVA.org:uu-507451 | |
| 003 | SwePub | |
| 008 | 230707s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5074512 URI |
| 024 | 7 | a https://doi.org/10.1016/j.jpba.2023.1154682 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nilsson Broberg, Malinu Uppsala universitet,Analytisk farmaceutisk kemi4 aut0 (Swepub:uu)malni160 |
| 245 | 1 0 | a Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control |
| 264 | 1 | b Elsevier,c 2023 |
| 338 | a electronic2 rdacarrier | |
| 520 | a LGD-3303 is a Selective Androgen Receptor Modulator (SARM) that is prohibited in both equine and human sports due to its anabolic properties. The aim of this study was to investigate the equine in vivo metabolite profile of LGD-3303 and identify drug metabolites that can be suitable as new and improved analytical targets for equine doping control. This was performed by an oral administration of 0.05 mg.kg(-1) LGD-3303 to horses, where blood and urine samples were collected up to 96 h after administration. The in vivo samples consisting of plasma, urine and hydrolyzed urine were analyzed utilizing ultra-high performance liquid chromatography hyphenated to a Q Exactive (TM) Orbitrap (TM) high resolution mass spectrometer with a heated electrospray ionization source. A total of eight metabolites of LGD-3303 were tentatively identified, including one carboxylated and several hydroxylated metabolites in combination with glucuronic acid conjugates. A monohydroxylated metabolite is suggested as an analytical target for doping control analysis of plasma and urine after hydrolysis with beta-glucuronidase, due to the high intensity and prolonged detection time in comparison to parent LGD-3303. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
| 653 | a Mass spectrometry | |
| 653 | a Selective androgen receptor modulator | |
| 653 | a LGD-3303 | |
| 653 | a Doping control | |
| 653 | a Metabolites | |
| 653 | a Equine | |
| 700 | 1 | a Knych, Heatheru Univ Calif Davis, Sch Vet Med, Kenneth L Maddy Equine Analyt Pharmacol Lab, Davis, CA 95616 USA.4 aut |
| 700 | 1 | a Bondesson, Ulfu Uppsala universitet,Analytisk farmaceutisk kemi4 aut0 (Swepub:uu)ulfbonde |
| 700 | 1 | a Pettersson, Curtu Uppsala universitet,Analytisk farmaceutisk kemi4 aut0 (Swepub:uu)curtps |
| 700 | 1 | a Tidstedt, Borjeu Natl Vet Inst SVA, Dept Chem Environm & Feed Hyg, S-75189 Uppsala, Sweden.4 aut |
| 700 | 1 | a Stanley, Scottu Univ Kentucky, Gluck Equine Res Ctr, Lexington, KY 40546 USA.4 aut |
| 700 | 1 | a Thevis, Mariou German Sport Univ Cologne, Inst Biochem, Ctr Prevent Doping Res, D-50933 Cologne, Germany.4 aut |
| 700 | 1 | a Hedeland, Mikaelu Uppsala universitet,Analytisk farmaceutisk kemi4 aut0 (Swepub:uu)mikahede |
| 710 | 2 | a Uppsala universitetb Analytisk farmaceutisk kemi4 org |
| 773 | 0 | t Journal of Pharmaceutical and Biomedical Analysisd : Elsevierg 233q 233x 0731-7085x 1873-264X |
| 856 | 4 | u https://doi.org/10.1016/j.jpba.2023.115468y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1781128/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507451 |
| 856 | 4 8 | u https://doi.org/10.1016/j.jpba.2023.115468 |
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