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Sökning: onr:"swepub:oai:DiVA.org:uu-509446" > Syndecan-4 is a mae...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008583naa a2200697 4500
001oai:DiVA.org:uu-509446
003SwePub
008230821s2023 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e1d3d19e-f007-4245-a2bf-29e92cd240c3
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5094462 URI
0247 a https://doi.org/10.1073/pnas.22148531202 DOI
0247 a https://lup.lub.lu.se/record/e1d3d19e-f007-4245-a2bf-29e92cd240c32 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pocas, Julianau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.;Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal.,University of Porto4 aut
2451 0a Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
264 1b Proceedings of the National Academy of Sciences (PNAS),c 2023
338 a electronic2 rdacarrier
520 a Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane pro-teoglycan, is highly expressed in intestinal subtype gastric tumors and that this sig -nature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and invasion. We also find that SDC4 decorated with heparan sulfate is efficiently sorted in extracellular vesicles (EVs). Interestingly, SDC4 in EVs regulates gastric cancer cell-derived EV organ distribution, uptake, and functional effects in recipient cells. Specifically, we show that SDC4 knockout disrupts the tropism of EVs for the common gastric cancer metastatic sites. Our findings set the basis for the molecular implications of SDC4 expression in gastric cancer cells and provide broader perspectives on the development of therapeutic strategies targeting the glycan-EV axis to limit tumor progression.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a syndecan-4
653 a heparan sulfate proteoglycans
653 a gastric cancer
653 a vesicles
653 a cancer cell invasion
7001 a Marques, Catarinau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.;Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal.,University of Porto4 aut
7001 a Gomes, Catarinau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Otake, Andreia Hanadau Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Canc Estado Sao Paulo, BR-01246000 Sao Paulo, Brazil.;Champalimaud Fdn, Champalimaud Physiol & Canc Programme, P-1400038 Lisbon, Portugal.4 aut
7001 a Pinto, Filipeu Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Ferreira, Marianau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Silva, Tiagou Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Faria-Ramos, Isabelu Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Matos, Ritau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Ribeiro, Ana Raquelu Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.,University of Porto4 aut
7001 a Senra, Emanuelu Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.,University of Porto4 aut
7001 a Cavadas, Brunou Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.,University of Porto4 aut
7001 a Batista, Silviau Champalimaud Fdn, Champalimaud Physiol & Canc Programme, P-1400038 Lisbon, Portugal.4 aut
7001 a Maia, Joanau Champalimaud Fdn, Champalimaud Physiol & Canc Programme, P-1400038 Lisbon, Portugal.4 aut
7001 a Macedo, Joana A.u Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.,University of Porto4 aut
7001 a Lima, Luisu Portuguese Oncol Inst Porto IPO Porto, Res Ctr IPO Porto CI IPOP RISE CI IPOP, Hlth Res Network, Expt Pathol & Therapeut Grp, P-4200072 Porto, Portugal.,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Afonso, Luis Pedrou Portuguese Oncol Inst Porto IPO Porto, Res Ctr IPO Porto CI IPOP RISE CI IPOP, Hlth Res Network, Expt Pathol & Therapeut Grp, P-4200072 Porto, Portugal.,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Ferreira, José Alexandreu Portuguese Oncol Inst Porto IPO Porto, Res Ctr IPO Porto CI IPOP RISE CI IPOP, Hlth Res Network, Expt Pathol & Therapeut Grp, P-4200072 Porto, Portugal.,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Santos, Lúcio Larau Portuguese Oncol Inst Porto IPO Porto, Res Ctr IPO Porto CI IPOP RISE CI IPOP, Hlth Res Network, Expt Pathol & Therapeut Grp, P-4200072 Porto, Portugal.,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Polónia, Antóniou University of Porto4 aut
7001 a Osório, Hugou Univ Porto, FMUP Fac Med, P-4200319 Porto, Portugal.,University of Porto4 aut
7001 a Belting, Mattiasu Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Neuroonkologi och neurodegeneration,Science for Life Laboratory, SciLifeLab,Lund Univ, Dept Clin Sci, Sect Oncol, S-22184 Lund, Sweden; Skane Univ Hosp, S-22185 Lund, Sweden,Tumörmikromiljön,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital4 aut0 (Swepub:lu)medk-mbe
7001 a Reis, Celso A.u Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.;Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal.;Univ Porto, FMUP Fac Med, P-4200319 Porto, Portugal.,University of Porto4 aut
7001 a Costa-Silva, Brunou Champalimaud Fdn, Champalimaud Physiol & Canc Programme, P-1400038 Lisbon, Portugal.4 aut
7001 a Magalhães, Anau Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.;Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal.,University of Porto4 aut
7102 a Univ Porto, i3S Inst Invest & Inovacao Saude, P-4200135 Porto, Portugal.;Univ Porto, IPATIMUP Inst Patol & Imunol Mol, P-4200465 Porto, Portugal.;Univ Porto, ICBAS Inst Ciencias Biomed Abel Salazar, P-4050313 Porto, Portugal.b University of Porto4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 120:20q 120:20x 0027-8424x 1091-6490
8564 u https://doi.org/10.1073/pnas.2214853120y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1789859/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1073/pnas.2214853120x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509446
8564 8u https://doi.org/10.1073/pnas.2214853120
8564 8u https://lup.lub.lu.se/record/e1d3d19e-f007-4245-a2bf-29e92cd240c3

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