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Association of beta...
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Ishak, DivanUppsala University,Uppsala universitet,Kardiologi,Uppsala Univ, Sweden
(författare)
Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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BMJ Publishing Group Ltd,2023
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-511070
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511070URI
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https://doi.org/10.1136/heartjnl-2022-322115DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193700URI
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https://lup.lub.lu.se/record/3855b4a9-a3ba-42e6-b312-a55fc42a5663URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152524115URI
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Språk:engelska
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Sammanfattning på:engelska
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Funding Agencies|Swedish State under the agreement between the Swedish Government and the County Councils (the ALF-agreement)
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Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD).Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish register for coronary heart disease. Follow-up started 1 year after hospitalisation (index date). Patients with heart failure or LVSD up until the index date were excluded. Patients were allocated into two groups according to BB treatment. Primary outcome was a composite of all-cause mortality, MI, unscheduled revascularisation and hospitalisation for heart failure. Outcomes were analysed using Cox and Fine-Grey regression models after inverse propensity score weighting.Results Overall, 34 253 (78.5%) patients received BB and 9365 (21.5%) did not at the index date 1 year following MI. The median age was 64 years and 25.5% were female. In the intention-to-treat analysis, the unadjusted rate of primary outcome was lower among patients who received versus not received BB (3.8 vs 4.9 events/100 person-years) (HR 0.76; 95% CI 0.73 to 1.04). Following inverse propensity score weighting and multivariable adjustment, the risk of the primary outcome was not different according to BB treatment (HR 0.99; 95% CI 0.93 to 1.04). Similar findings were observed when censoring for BB discontinuation or treatment switch during follow-up.Conclusion Evidence from this nationwide cohort study suggests that BB treatment beyond 1 year of MI for patients without heart failure or LVSD was not associated with improved cardiovascular outcomes.
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Aktaa, SulemanLeeds Teaching Hosp NHS Trust, Dept Cardiol, Leeds, England.;Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Div Epidemiol & Biostat, Leeds, England,Leeds School of Medicine,Leeds Teaching Hospitals NHS Trust
(författare)
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Lindhagen, LarsUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Clin Res Ctr, Sweden(Swepub:uu)lla11670
(författare)
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Alfredsson, JoakimLinköping University,Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)joaal38
(författare)
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Dondo, Tatendashe BernadetteUniv Leeds, Leeds Inst Cardiovasc & Metab Med, Div Epidemiol & Biostat, Leeds, England,Leeds School of Medicine
(författare)
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Held, ClaesUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Sweden; Uppsala Clin Res Ctr, Sweden(Swepub:uu)clahe947
(författare)
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Jernberg, TomasKarolinska Institutet
(författare)
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Yndigegn, TroelsLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärtinflammationsforskningsgrupp,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiac Inflammation Research Group,Lund University Research Groups(Swepub:lu)med-toy
(författare)
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Gale, Chris P.Leeds Teaching Hosp NHS Trust, Dept Cardiol, Leeds, England.;Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Div Epidemiol & Biostat, Leeds, England,Leeds Teaching Hospitals NHS Trust,Leeds School of Medicine
(författare)
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Batra, GoravUppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, S-75105 Uppsala, Sweden.(Swepub:uu)gorba357
(författare)
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Uppsala universitetKardiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Heart: BMJ Publishing Group Ltd109:15, s. 1159-11651355-60371468-201X
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Ishak, Divan
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Aktaa, Suleman
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Lindhagen, Lars
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Alfredsson, Joak ...
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Dondo, Tatendash ...
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Held, Claes
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Jernberg, Tomas
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Yndigegn, Troels
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Gale, Chris P.
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Batra, Gorav
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