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Risks and treatment...
Risks and treatment related aspects of COVID-19 infection in patients with ANCA-associated vasculitis
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- Antovic, A. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Karolinska Univ Hosp, Dept Renal Med, CLINTEC, Karolinska Inst, Stockholm, Sweden.,Uppsala Univ, Sweden
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- Bruchfeld, Annette (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Univ Hosp, Sweden
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- Ekland, J. (författare)
- Uppsala universitet,Reumatologi,Uppsala Univ, Sweden
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- Lovstrom, B. (författare)
- Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.
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- Hugelius, A. (författare)
- Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.
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- Borjesson, O. (författare)
- Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.
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- Knight, Ann (författare)
- Uppsala universitet,Reumatologi
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- Gunnarsson, I (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med, Div Rheumatol, Solna, Sweden;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden. (creator_code:org_t)
- 2022-09-20
- 2023
- Engelska.
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Ingår i: Scandinavian Journal of Rheumatology. - : Taylor & Francis. - 0300-9742 .- 1502-7732. ; 52:4, s. 418-423
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) require immunosuppressive therapy for disease control and relapse prevention and may be at risk for severe coronavirus disease 2019 (COVID-19). The study objective was to analyse risk factors and outcomes of COVID-19 in well-characterized AAV patients. Method Data were retrieved from March 2020 to May 2021 from medical records of AAV cohorts in Stockholm and Uppsala, Sweden. COVID-19 was confirmed by positive PCR test or by ELISA. Severe COVID-19 was defined as need for non-invasive ventilation, intensive care unit care, and/or death. Age, gender, ANCA antibody type, ongoing immunosuppressive medication, and estimated glomerular filtration rate were recorded. Results The cohort comprised 310 AAV patients, of whom 29 (9%) were diagnosed with COVID-19. Four deaths were attributed to COVID-19. Fifteen patients (52%) were on prednisolone in the COVID-19 group and 130 (46%) in the non-COVID group, with significantly higher doses in COVID-19 patients (p < 0.01). Ongoing induction therapy was more prevalent in the COVID-19 group (p < 0.01). Severe COVID-19 was diagnosed in 9/29 (31%). Significant risk factors for severe COVID-19 were impaired kidney function (p = 0.01) and more intense immunosuppressive therapy (p = 0.02), with a trend for age (p = 0.07). Maintenance therapy with rituximab was not associated with severe COVID-19. Conclusions Our findings highlight risks and suggest that more attention should be given to optimal AAV treatment in a pandemic situation. They also emphasize the need for continued shielding, mitigation strategies, and effective vaccination of AAV patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
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