onr:"swepub:oai:DiVA.org:uu-511733"
Sökning: onr:"swepub:oai:DiVA.org:uu-511733" > Fusobacterium nucle...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04920naa a2200517 4500 | |
| 001 | oai:DiVA.org:uu-511733 | |
| 003 | SwePub | |
| 008 | 230922s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5117332 URI |
| 024 | 7 | a https://doi.org/10.1111/cas.157812 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Xin, Yiweiu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 245 | 1 0 | a Fusobacterium nucleatum- induced exosomal HOTTIP promotes gastric cancer progression through the microRNA-885-3p/EphB2 axis |
| 264 | c 2023-03-10 | |
| 264 | 1 | b John Wiley & Sons,c 2023 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Recent studies have reported that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer-derived exosomes contain key regulatory noncoding RNAs and are a crucial medium of intercellular communication. However, the function and regulatory mechanism of exosomes (Fn-GCEx) secreted from Fn-infected GC cells remains unclear. In this study, Fn-GCEx enhanced the proliferation, migration, and invasion capacity of GC cells in vitro, as well as tumor growth and metastasis in vivo. HOTTIP was also upregulated in GC cells treated with Fn-GCEx. Moreover, knockdown of HOTTIP weakened the effects of Fn-GCEx in recipient GC cells. Mechanistically, HOTTIP promoted EphB2 expression by sponging microRNA (miR)-885-3p, thus activating the PI3K/AKT pathway in Fn-GCEx treated GC cells. Overall, Fn infection induced the upregulation of exosomal HOTTIP from GC cells that subsequently promoted GC progression through the miR-885-3p/EphB2/PI3K/AKT axis. Herein, we identify a potential molecular pathway and therapeutic target for GC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Exosome | |
| 653 | a Fusobacterium nucleatum | |
| 653 | a Gastric cancer | |
| 653 | a HOTTIP | |
| 653 | a lncRNA | |
| 700 | 1 | a Li, Xinyangu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Zhang, Mengjiaou Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Shang, Ziqiu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Luo, Zhengdongu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Wang, Yifengu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Gui, Xinruu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Liu, Qiu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Li, Tingtingu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Zeng, Shunjieu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Schiöth, Helgi B.u Uppsala universitet,Funktionell farmakologi och neurovetenskap4 aut0 (Swepub:uu)helgschi |
| 700 | 1 | a Zhang, Xinu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 700 | 1 | a Zhang, Yiu Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.4 aut |
| 710 | 2 | a Shandong Univ, Qilu Hosp, Dept Clin Lab, Jinan, Peoples R China.;Shandong Engn Res Ctr Biomarker & Artificial Inte, Jinan, Peoples R China.b Funktionell farmakologi och neurovetenskap4 org |
| 773 | 0 | t Cancer Scienced : John Wiley & Sonsg 114:6, s. 2360-2374q 114:6<2360-2374x 1347-9032x 1349-7006 |
| 856 | 4 | u https://doi.org/10.1111/cas.15781y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1799419/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511733 |
| 856 | 4 8 | u https://doi.org/10.1111/cas.15781 |
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