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Structural Characte...
Structural Characterization of Nanoparticle-Supported Lipid Bilayer Arrays by Grazing Incidence X-ray and Neutron Scattering
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- Paracini, Nicolò (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Fac Hlth & Soc, Res Ctr Biointerfaces, Dept Biomed Sci & Biofilms, S-20506 Malmö, Sweden.
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- Gutfreund, Philipp (författare)
- Inst Laue Langevin ILL, F-38000 Grenoble, France.,Institut Laue-Langevin (ILL), Grenoble, France
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- Welbourn, Rebecca (författare)
- Rutherford Appleton Lab, ISIS Neutron & Muon Source, STFC, Harwell OX11 0QX, Oxon, England.,ISIS Neutron & Muon Source, STFC, Rutherford Appleton Laboratory, Harwell, Oxfordshir, U.K
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- Gonzalez-Martinez, Juan F (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Fac Hlth & Soc, Res Ctr Biointerfaces, Dept Biomed Sci & Biofilms, S-20506 Malmö, Sweden.
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- Zhu, Kexin (författare)
- Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore.,School of Biological Sciences, Nanyang Technological University, Singapore
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- Miao, Yansong (författare)
- Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore.,School of Biological Sciences, Nanyang Technological University, Singapore
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- Yepuri, Nageshwar (författare)
- Australian Nucl Sci & Technol Org ANSTO, Natl Deuterat Facil, Lucas Heights, NSW 2234, Australia.,National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), Lucas Heights, Australia
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- Darwish, Tamim A. . (författare)
- Australian Nucl Sci & Technol Org ANSTO, Natl Deuterat Facil, Lucas Heights, NSW 2234, Australia.,National Deuteration Facility, Australian Nuclear Science and Technology Organization (ANSTO), Lucas Heights, Australia
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- Garvey, Christopher (författare)
- Tech Univ Munich, Heinz Maier Leibnitz Zentrum MLZ, D-85748 Garching, Germany.,Heinz Maier-Leibnitz Zentrum (MLZ), Technische Universität München, Garching, Germany
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- Waldie, Sarah (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Fac Hlth & Soc, Res Ctr Biointerfaces, Dept Biomed Sci & Biofilms, S-20506 Malmö, Sweden.
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- Larsson, Johan (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Fac Hlth & Soc, Res Ctr Biointerfaces, Dept Biomed Sci & Biofilms, S-20506 Malmö, Sweden.
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- Wolff, Max (författare)
- Uppsala universitet,Materialfysik,Department of Physics and Astronomy, Uppsala University
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- Cárdenas, Marité (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Fac Hlth & Soc, Res Ctr Biointerfaces, Dept Biomed Sci & Biofilms, S-20506 Malmö, Sweden.;Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore.
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(creator_code:org_t)
- 2023-01-10
- 2023
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 15:3, s. 3772-3780
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Arrays of nanoparticle-supported lipid bilayers (nanoSLB) are lipid-coated nanopatterned interfaces that provide a platform to study curved model biological membranes using surface-sensitive techniques. We combined scattering techniques with direct imaging, to gain access to sub-nanometer scale structural information on stable nanoparticle monolayers assembled on silicon crystals in a noncovalent manner using a Langmuir-Schaefer deposition. The structure of supported lipid bilayers formed on the nanoparticle arrays via vesicle fusion was investigated using a combination of grazing incidence X-ray and neutron scattering techniques complemented by fluorescence microscopy imaging. Ordered nanoparticle assemblies were shown to be suitable and stable substrates for the formation of curved and fluid lipid bilayers that retained lateral mobility, as shown by fluorescence recovery after photobleaching and quartz crystal microbalance measurements. Neutron reflectometry revealed the formation of high-coverage lipid bilayers around the spherical particles together with a flat lipid bilayer on the substrate below the nanoparticles. The presence of coexisting flat and curved supported lipid bilayers on the same substrate, combined with the sub-nanometer accuracy and isotopic sensitivity of grazing incidence neutron scattering, provides a promising novel approach to investigate curvature-dependent membrane phenomena on supported lipid bilayers.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- nanoparticle-supported lipid bilayers
- nanoSLB
- membrane curvature
- model membranes
- neutron reflectometry
- GISANS
- GISAXS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Paracini, Nicolò
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Gutfreund, Phili ...
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Welbourn, Rebecc ...
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Gonzalez-Martine ...
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Zhu, Kexin
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Miao, Yansong
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Yepuri, Nageshwa ...
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Darwish, Tamim A ...
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Garvey, Christop ...
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Waldie, Sarah
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Larsson, Johan
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Wolff, Max
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Cárdenas, Marité
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biofysik
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
- Artiklar i publikationen
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ACS Applied Mate ...
- Av lärosätet
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Uppsala universitet
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Malmö universitet