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- Haavisto, AnuKarolinska Institutet,Univ Helsinki, Dept Psychol & Logoped, Helsinki, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden. (författare)
Premature ovarian insufficiency and chance of pregnancy after childhood cancer : A population-based study (the Fex-Can study)
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
- Wiley-Blackwell,2023
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-512587
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512587URI
- https://doi.org/10.1002/ijc.34541DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208068URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152599736URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Endocrine complications are a common late effect after childhood cancer. Our study assessed the prevalence and predictors of premature ovarian insufficiency (POI) and prospects of pregnancy in young female survivors. This nationwide study combined registry and survey data for female childhood cancer survivors aged 19 to 40 years, identified through the National Quality Registry for Childhood Cancer in Sweden. Of 1989 approached young women, 1333 (67%) participated by completing a survey. Median age at diagnosis 1981 to 2017 was 6 (range 0-17) and at study 28 (19-40) years. There were two indicators of POI, induced puberty reported in 5.3% and estrogen replacement therapy (ERT) in 9.3% at assessment. In separate logistic regression analyses (P < .001), induced puberty and ERT were significantly predicted by hematopoietic stem cell transplantation (HSCT), abdominal irradiation, central nervous system irradiation and chemotherapy. ERT was also associated with older age at diagnosis. Of the 626 women (48% of responders) who had tried to become pregnant, 25% had undergone fertility investigations and 72% reported having a biological child. Treatment with HSCT was associated with 5.4 times the odds of needing fertility investigations (P < .001). Having a biological child was associated with non-HSCT treatment, but also with ever having had a partner and older age at the time of study (all P < .001). In conclusion, the majority of those female childhood cancer survivors who had tried to conceive were able to successfully give birth. However, a small identifiable group of female survivors are at risk of subfertility and early menopause.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- childhood cancer
- estrogen replacement therapy
- late-effects
- registry study
- subfertility
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Wettergren, LenaKarolinska Institutet,Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)lewet534 (författare)
- Lampic, Claudia,1964-Karolinska Institutet,Umeå universitet,Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Umeå Univ, Dept Psychol, Umeå, Sweden.,Institutionen för psykologi,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden(Swepub:umu)clla0025 (författare)
- Lahteenmaki, Päivi M.Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.;Univ Turku, FICANWEST, Turku, Finland.,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric and Adolescent Medicine, Turku University Hospital, Turku, Finland; FICANWEST, University of Turku, Turku, Finland (författare)
- Jahnukainen, KirsiKarolinska Institutet,Univ Helsinki, Childrens Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, NORDFERTIL Res Lab Stockholm, Stockholm, Sweden. (författare)
- Karolinska InstitutetUniv Helsinki, Dept Psychol & Logoped, Helsinki, Finland.;Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:International Journal of Cancer: Wiley-Blackwell153:3, s. 644-6530020-71361097-0215
Internetlänk
- https://doi.org/10.1002/ijc.34541Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1800801/FULLTEXT01.pdffulltext:print
- https://umu.diva-portal.org/smash/get/diva2:1759508/FULLTEXT02.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512587
- https://doi.org/10.1002/ijc.34541
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208068
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152599736
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