Search: WFRF:(Dukat Andre)
> (2023) >
IGFBP-7 and Outcome...
IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction : Findings From DAPA-HF.
-
Adamson, Carly (author)
-
Welsh, Paul (author)
-
Docherty, Kieran F. (author)
-
show more...
-
de Boer, Rudolf A. (author)
-
Diez, Mirta (author)
-
Drozdz, Jaroslaw (author)
-
Dukat, Andre (author)
-
Inzucchi, Silvio E. (author)
-
Kober, Lars (author)
-
Kosiborod, Mikhail N. (author)
-
- Ljungman, Charlotta, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
-
Martinez, Felipe A. (author)
-
Ponikowski, Piotr (author)
-
Sabatine, Marc S. (author)
-
Morrow, David A. (author)
-
Lindholm, Daniel (author)
-
Hammarstedt, Ann (author)
-
Boulton, David W. (author)
-
Greasley, Peter J. (author)
-
Langkilde, Anna Maria (author)
-
Solomon, Scott D. (author)
-
Sattar, Naveed (author)
-
McMurray, John J. V. (author)
-
Jhund, Pardeep S. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
-
In: JACC. Heart failure. - : Elsevier BV. - 2213-1779 .- 2213-1787. ; 11:3, s. 291-304
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Insulin-like growth factor-binding protein-7 (IGFBP-7) has been proposed as a potential prognostic biomarker in heart failure (HF), but the association between elevation in IGFBP-7 and HF outcomes in ambulant patients with heart failure with reduced ejection fraction (HFrEF) is unknown. OBJECTIVES: The authors addressed this question in a post hoc analysis of the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) trial. METHODS: The primary outcome was a composite of cardiovascular death or a worsening HF event. The risk of adverse outcome was compared across tertiles of IGFBP-7 concentration by means of Cox proportional hazard models adjusted for N-terminal pro-B- type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT). The efficacy of randomized treatment across IGFBP-7 tertiles was assessed. Change in IGFBP-7 at 12 months was compared with the use of geometric means. RESULTS: A total of 3,158 patients had IGFBP-7 measured at baseline, and 2,493 had a repeated measure at 12 months. Patients in the highest tertile of IGFBP-7 had evidence of more advanced HFrEF. The adjusted HR for the primary endpoint in tertile 3, compared with tertile 1, was 1.48 (95% CI: 1.17-1.88). There was no modification of the benefit of dapagliflozin by baseline IGFBP-7 (P interaction = 0.34). Dapagliflozin did not change IGFBP-7 levels over 1 year (P = 0.34). CONCLUSIONS: Higher IGFBP-7 in patients with HFrEF was associated with worse clinical profile and an increased risk of adverse clinical outcomes. IGFBP-7 provided prognostic information incremental to clinical variables, NT-proBNP, and hsTnT. The benefit of dapagliflozin was not modulated by IGFBP-7 level. (Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure [DAPA-HF]; NCT03036124).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- *Heart Failure/drug therapy
- *Ventricular Dysfunction
- Left
- biomarker
- dapagliflozin
- heart failure
- Humans
- Insulin-Like Growth Factor Binding Proteins
- insulin-like growth factor-binding protein-7
- Proportional Hazards Models
- SGLT2 inhibitor
- Stroke Volume
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Adamson, Carly
-
Welsh, Paul
-
Docherty, Kieran ...
-
de Boer, Rudolf ...
-
Diez, Mirta
-
Drozdz, Jaroslaw
-
show more...
-
Dukat, Andre
-
Inzucchi, Silvio ...
-
Kober, Lars
-
Kosiborod, Mikha ...
-
Ljungman, Charlo ...
-
Martinez, Felipe ...
-
Ponikowski, Piot ...
-
Sabatine, Marc S ...
-
Morrow, David A.
-
Lindholm, Daniel
-
Hammarstedt, Ann
-
Boulton, David W ...
-
Greasley, Peter ...
-
Langkilde, Anna ...
-
Solomon, Scott D ...
-
Sattar, Naveed
-
McMurray, John J ...
-
Jhund, Pardeep S ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
JACC. Heart fail ...
- By the university
-
Uppsala University
-
University of Gothenburg