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Reproduction patter...
Reproduction patterns among classical Hodgkin lymphoma survivors treated with BEACOPP and ABVD in Sweden, Denmark and Norway-A population-based matched cohort study
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- Entrop, Joshua P. (författare)
- Karolinska Institutet
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- Weibull, Caroline E. (författare)
- Karolinska Institutet
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- Smedby, Karin E. (författare)
- Karolinska Institutet
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- Jakobsen, Lasse H. (författare)
- Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark.;Aalborg Univ, Dept Math Sci, Aalborg, Denmark.
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- Øvlisen, Andreas K. (författare)
- Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark.
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- Molin, Daniel, 1969- (författare)
- Uppsala universitet,Cancerimmunterapi
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Marklund, Anna (författare)
- Karolinska Univ Hosp, Dept Reprod Med, Div Gynecol & Reprod, Stockholm, Sweden.
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- Holte, Harald (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Fosså, Alexander (författare)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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Smeland, Knut B. (författare)
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- El-Galaly, Tarec C. (författare)
- Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark.;Odense Univ Hosp, Dept Hematol, Odense, Denmark.
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- Eloranta, Sandra (författare)
- Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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Karolinska Institutet Aalborg Univ Hosp, Clin Canc Res Ctr, Dept Hematol, Aalborg, Denmark;Aalborg Univ, Dept Math Sci, Aalborg, Denmark. (creator_code:org_t)
- Wiley-Blackwell, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 153:4, s. 723-731
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Childbirth rates in classical Hodgkin lymphoma (cHL) survivors have historically been reduced compared to the general population. Understanding if contemporary treatment protocols are associated with reduced fertility is crucial as treatment guidelines shift toward more liberal use of intensive chemotherapy. We identified 2834 individuals aged 18-40 years with cHL in Swedish and Danish lymphoma registers, and in the clinical database at Oslo University Hospital diagnosed 1995-2018, who were linked to national medical birth registers. Cox regression adjusted for stage, performance status, year, and age at diagnosis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) contrasting time to first childbirth by treatment groups (ABVD, 2-4 BEACOPP, 6-8 BEACOPP) up to 10 years after diagnosis. Overall, 74.8% of patients were treated with ABVD, 3.1% with 2-4 BEACOPP and 11.2% with 6-8 BEACOPP. Adjusted HRs comparing childbirth rates in individuals treated with 6-8 BEACOPP, and 2-4 BEACOPP to ABVD were 0.53 (CI: 0.36-0.77) and 0.33 (CI: 0.12-0.91) for males, and 0.91 (CI: 0.61-1.34) and 0.38 (CI: 0.12-1.21) for females. Cumulative incidence of childbirths after 10 years was 19.8% (CI: 14.5%-27.0%) for males and 34.3% (CI: 25.8%-45.6%) for females treated with 6-8 BEACOPP. Proportions of children born after assisted reproductive technique (ART) treatments were 77.4% (CI: 60.2-88.6%) for males following 6-8 BEACOPP, and <11% for females. Among ABVD treated patients the corresponding proportions were 12.2% (CI: 8.5%-17.3%) and 10.6% (CI: 7.4%-14.9%). BEACOPP treatment is associated with decreased childbirth rates compared to ABVD in male, but not female, cHL patients, despite widespread access to ART in the Nordics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- chemotherapy
- fertility
- Hodgkin disease
- late effects of cancer treatment
- survivorship
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Entrop, Joshua P ...
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Weibull, Carolin ...
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Smedby, Karin E.
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Jakobsen, Lasse ...
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Øvlisen, Andreas ...
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Molin, Daniel, 1 ...
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Glimelius, Ingri ...
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Marklund, Anna
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Holte, Harald
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Fosså, Alexander
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Smeland, Knut B.
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El-Galaly, Tarec ...
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Eloranta, Sandra
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- MEDICIN OCH HÄLSOVETENSKAP
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Uppsala universitet
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Karolinska Institutet