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Associations of Ins...
Associations of Insomnia With Insulin Resistance Traits : A Cross-sectional and Mendelian Randomization Study
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- Wang, Xiaoyu (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Zhao, Chenhao (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Feng, Hongliang (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510000, Guangdong, Peoples R China.
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- Li, Guohua (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- He, Lei (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Yang, Lulu (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510000, Guangdong, Peoples R China.
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- Liang, Yan (författare)
- Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510000, Guangdong, Peoples R China.
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- Tan, Xiao (författare)
- Karolinska Institutet,Uppsala universitet,Lung- allergi- och sömnforskning
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- Xu, Yanmin (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Cui, Ruixiang (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Sun, Yujing (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Guo, Sheng (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Zhao, Guoan (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.
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- Zhang, Jihui (författare)
- Guangzhou Med Univ, Ctr Sleep & Circadian Med, Affiliated Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China.;Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, Hong Kong 999077, Peoples R China.;Southern Med Univ, Zhujiang Hosp, Sch Clin Med 2, Guangzhou 510280, Peoples R China.;Guangzhou Med Univ, Ctr Sleep & Circadian Med, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
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- Ai, Sizhi (författare)
- Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China.;Guangzhou Med Univ, Ctr Sleep & Circadian Med, Affiliated Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China.;Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui, Peoples R China.
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Xinxiang Med Univ, Life Sci Ctr, Dept Cardiol, Affiliated Hosp 1, Weihui 453100, Peoples R China Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510000, Guangdong, Peoples R China. (creator_code:org_t)
- 2023-02-16
- 2023
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 108:8, s. e574-e582
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Context: Insomnia is associated with insulin resistance (IR) in observational studies; however, whether insomnia is causally associated with IR remains unestablished.Objective: This study aims to estimate the causal associations of insomnia with IR and its related traits.Methods: In primary analyses, multivariable regression (MVR) and 1-sample Mendelian randomization (1SMR) analyses were performed to estimate the associations of insomnia with IR (triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol [TG/HDL-C] ratio) and its related traits (glucose level, TG, and HDL-C) in the UK Biobank. Thereafter, 2-sample MR (2SMR) analyses were used to validate the findings from primary analyses. Finally, the potential mediating effects of IR on the pathway of insomnia giving rise to type 2 diabetes (T2D) were examined using a 2-step MR design.Results: Across the MVR, 1SMR, and their sensitivity analyses, we found consistent evidence suggesting that more frequent insomnia symptoms were significantly associated with higher values of triglyceride-glucose index (MVR, beta = 0.024, P < 2.00E-16; 1SMR, beta = 0.343, P < 2.00E-16), TG/HDL-C ratio (MVR, beta = 0.016, P = 1.75E-13; 1SMR, beta = 0.445, P < 2.00E-16), and TG level (MVR, beta = 0.019 log mg/dL, P < 2.00E-16, 1SMR: beta = 0.289 log mg/dL, P < 2.00E-16) after Bonferroni adjustment. Similar evidence was obtained by using 2SMR, and mediation analysis suggested that about one-quarter (25.21%) of the association between insomnia symptoms and T2D was mediated by IR.Conclusions: This study provides robust evidence supporting that more frequent insomnia symptoms are associated with IR and its related traits across different angles. These findings indicate that insomnia symptoms can be served as a promising target to improve IR and prevent subsequent T2D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- insomnia
- triglycerides
- HDL cholesterol
- glucose
- causality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wang, Xiaoyu
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Zhao, Chenhao
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Feng, Hongliang
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Li, Guohua
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He, Lei
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Yang, Lulu
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Liang, Yan
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Tan, Xiao
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Xu, Yanmin
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Cui, Ruixiang
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Sun, Yujing
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Guo, Sheng
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Zhao, Guoan
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Zhang, Jihui
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Ai, Sizhi
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet