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CD4+ T cell-induced...
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Kruse, BastianOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Springer Nature,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-512802
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512802URI
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https://doi.org/10.1038/s41586-023-06199-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Title in Web of Science: CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours
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Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to directly recognize and kill tumour cells1,2,3. These strategies are limited by the emergence of major histocompatibility complex (MHC)-deficient tumour cells and the formation of an immunosuppressive tumour microenvironment4,5,6. The ability of CD4+ effector cells to contribute to antitumour immunity independently of CD8+ T cells is increasingly recognized, but strategies to unleash their full potential remain to be identified7,8,9,10. Here, we describe a mechanism whereby a small number of CD4+ T cells is sufficient to eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting. The CD4+ effector T cells preferentially cluster at tumour invasive margins where they interact with MHC-II+CD11c+ antigen-presenting cells. We show that T helper type 1 cell-directed CD4+ T cells and innate immune stimulation reprogramme the tumour-associated myeloid cell network towards interferon-activated antigen-presenting and iNOS-expressing tumouricidal effector phenotypes. Together, CD4+ T cells and tumouricidal myeloid cells orchestrate the induction of remote inflammatory cell death that indirectly eradicates interferon-unresponsive and MHC-deficient tumours. These results warrant the clinical exploitation of this ability of CD4+ T cells and innate immune stimulators in a strategy to complement the direct cytolytic activity of CD8+ T cells and natural killer cells and advance cancer immunotherapies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Buzzai, Anthony C.Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Shridhar, NaveenOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Braun, Andreas D.Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Gellert, SusanOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Knauth, KristinOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Pozniak, JoannaVIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
(författare)
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Peters, JohannesOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Dittmann, PaulinaOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Mengoni, MiriamOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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van der Sluis, Tetje CorneliaOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Höhn, SimonOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Antoranz, AsierKatholieke Univ Leuven, Dept Imaging & Pathol, Translat Cell & Tissue Res, Leuven, Belgium.
(författare)
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Krone, AnnaOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Fu, YanOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Yu, Di,1985-Uppsala universitet,Cancerimmunterapi(Swepub:uu)diayu422
(författare)
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Essand, MagnusUppsala universitet,Cancerimmunterapi(Swepub:uu)magnessa
(författare)
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Geffers, RobertHelmholtz Ctr Infect Res, Braunschweig, Germany.
(författare)
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Mougiakakos, DimitriosOtto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.;Otto von Guericke Univ, Dept Hematol, Univ Hosp, Magdeburg, Germany.
(författare)
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Kahlfuss, SaschaOtto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Kashkar, HamidUniv Cologne, Inst Mol Immunol, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
(författare)
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Gaffal, EvelynOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Bosisio, Francesca M.UZ Leuven, Dept Pathol, Leuven, Belgium.
(författare)
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Bechter, OliverUZ Leuven, Dept Gen Med Oncol, Leuven, Belgium.
(författare)
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Rambow, FlorianUniv Hosp Essen, Inst Med IKIM, Dept Appl Computat Canc Res, Essen, Germany.;Univ Duisburg Essen, Essen, Germany.
(författare)
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Marine, Jean-ChristopheVIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
(författare)
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Kastenmüller, WolfgangInst Syst Immunol, Wurzburg, Germany.
(författare)
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Müller, Andreas J.Otto von Guericke Univ, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Tüting, ThomasOtto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.
(författare)
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Otto von Guericke Univ, Univ Hosp, Dept Dermatol, Lab Expt Dermatol, Magdeburg, Germany.;Otto von Guericke Univ, Hlth Campus Immunol Infectiol & Inflammat GC I3, Magdeburg, Germany.VIB, Ctr Canc Biol, Lab Mol Canc Biol, Leuven, Belgium.;Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, Leuven, Belgium.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature: Springer Nature618:7967, s. 1033-10400028-08361476-4687
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Kruse, Bastian
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Buzzai, Anthony ...
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Shridhar, Naveen
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Braun, Andreas D ...
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Gellert, Susan
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Knauth, Kristin
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visa fler...
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Pozniak, Joanna
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Peters, Johannes
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Dittmann, Paulin ...
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Mengoni, Miriam
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van der Sluis, T ...
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Höhn, Simon
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Antoranz, Asier
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Krone, Anna
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Fu, Yan
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Yu, Di, 1985-
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Essand, Magnus
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Geffers, Robert
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Mougiakakos, Dim ...
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Kahlfuss, Sascha
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Kashkar, Hamid
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Gaffal, Evelyn
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Bosisio, Frances ...
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Bechter, Oliver
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Rambow, Florian
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Marine, Jean-Chr ...
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Kastenmüller, Wo ...
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Müller, Andreas ...
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Tüting, Thomas
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