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Analyses of Extende...
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India
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- Kumar Dey, Tushar (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Biosciences, International Livestock Research Institute, Nairobi 00100, Kenya; ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru 560064, India
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- Lindahl, Johanna Frida (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Biosciences, International Livestock Research Institute, Nairobi 00100, Kenya; Department of Clinical Sciences, Swedish University of Agricultural Sciences, 75007 Uppsala, Sweden,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,International Livestock Research Institute (ILRI),Uppsala University
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- Lundkvist, Åke (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Grace, Delia (författare)
- Department of Biosciences, International Livestock Research Institute, Nairobi 00100, Kenya;Food and Markets Department, Natural Resources Institute, Chatham Maritime ME4 4TB, UK
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- Deka, Ram Pratim (författare)
- International Livestock Research Institute, Regional Office for South Asia, New Delhi 110012, India
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- Shome, Rajeswari (författare)
- ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru 560064, India
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- Bandyopadhyay, Samiran (författare)
- Eastern Regional Station, ICAR-Indian Veterinary Research Institute, Kolkata 700037, India
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- Goyal, Naresh Kumar (författare)
- Dairy Microbiology Division, National Dairy Research Institute, Karnal 132001, India
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- Sharma, Garima (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Biosciences, International Livestock Research Institute, Nairobi 00100, Kenya
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- Shome, Bibek Ranjan (författare)
- ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru 560064, India
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(creator_code:org_t)
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- MDPI, 2023
- 2023
- Engelska.
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Ingår i: Antibiotics. - : MDPI. - 2079-6382. ; 12:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://pub.epsilon.... (primary) (Raw object) (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- The consumption of milk contaminated with antibiotic-resistant bacteria poses a significant health threat to humans. This study aimed to investigate the prevalence of Enterobacteriaceae producing β-lactamases (ESBL, MBL, and AmpC) in cow and buffalo milk samples from two Indian states, Haryana and Assam. A total of 401 milk samples were collected from dairy farmers and vendors in the specified districts. Microbiological assays, antibiotic susceptibility testing, and PCR-based genotyping were employed to analyze 421 Gram-negative bacterial isolates. The overall prevalence of β-lactamase genes was 10% (confidence interval (CI) (7–13)), with higher rates in Haryana (13%, CI (9–19)) compared to Assam (7%, CI (4–11)). The identified β-lactamase genes in isolates were blaCMY, blaMOX, blaFOX, blaEBC, and blaDHA, associated with AmpC production. Additionally, blaCTX-M1, blaSHV, and blaTEM were detected as ESBL producers, while blaVIM, blaIMP, blaSPM, blaSIM, and blaGIM were identified as MBL producers. Notably, Shigella spp. were the dominant β-lactamase producers among identified Enterobacteriaceae. This study highlights the presence of various prevalent β-lactamase genes in milk isolates, indicating the potential risk of antimicrobial-resistant bacteria in dairy products. The presence of β-lactam resistance raises concern as this could restrict antibiotic options for treatment. The discordance between genotypic and phenotypic methods emphasizes the necessity for comprehensive approaches that integrate both techniques to accurately assess antibiotic resistance. Urgent collaborative action incorporating rational and regulated use of antibiotics across the dairy value chain is required to address the global challenge of β-lactam resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Nyckelord
- antimicrobial resistance
- AMR
- enterobacteriaceae
- β-lactamase
- ESBL
- MBL
- AmpC
- dairy milk
- intensification
- food safety
- Mikrobiologi
- Microbiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Kumar Dey, Tusha ...
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Lindahl, Johanna ...
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Lundkvist, Åke
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Grace, Delia
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Deka, Ram Pratim
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Shome, Rajeswari
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Bandyopadhyay, S ...
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Goyal, Naresh Ku ...
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Sharma, Garima
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Shome, Bibek Ran ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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MEDICIN OCH HÄLS ...
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- Artiklar i publikationen
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Antibiotics
- Av lärosätet
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Uppsala universitet
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Sveriges Lantbruksuniversitet