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Importance of CD23 ...
Importance of CD23 for collagen-induced arthritis : delayed onset and reduced severity in CD23-deficient mice
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- Kleinau, Sandra (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Martinsson, Pernilla (författare)
- Uppsala universitet,Hematologi och immunologi
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Gustavsson, Susanne (författare)
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- Heyman, Birgitta (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Journal of Immunology. - 0022-1767 .- 1550-6606. ; 162:7, s. 4266-4270
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Increased expression of the low affinity receptor for IgE, FcepsilonRII/CD23 has been observed in rheumatoid arthritis. In view of this, we have investigated the expression and influence of CD23 in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. CD23+ cells were analyzed in lymph nodes of DBA/1 mice immunized with bovine collagen type II (BCII) in CFA or with CFA only. The percentage of CD23+ lymph node cells was increased in both BCII/CFA- and CFA-immunized mice at 1, 3, and 7 wk after immunization compared with unimmunized mice, indicating a role for the adjuvant to trigger general inflammation and CD23 expression. To investigate the functional role of CD23 in CIA, CD23-deficient mice on the DBA/1 genetic background were studied. After immunization with BCII/CFA, these mice developed CIA with delayed onset and reduced severity compared with wild-type mice. These findings suggest that an increased number of CD23+ cells is part of an inflammatory response and that CD23 expression is of pathogenic importance in the arthritic process.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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