Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes: A nationwide study in Sweden

Haas, JosephineKarolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden. (författare)

Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes : A nationwide study in Sweden

Aims: To examine time-trends in BMI-distributions of young females with and without type 1 diabetes (T1D), with focus on the upper half of the distribution i.e., the median and above, and to explore if overweight and obesity independently increase risk of diabetes angiopathy.Methods: Population-based cohort study of 3,473 females with T1D, 16-35 years, identified in the Swedish National Diabetes Registers, January 2005 to October 2015, and 8,487 females from the background population. BMI-distributions were examined using kernel density estimates and quantile regression. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for angiopathy in overweight/obese subjects were estimated with adjusted Cox regression.Results: The BMI-distribution in females with T1D was right shifted to that of the background population (p < 0.001). The 90th percentile and median BMI increased equally overtime in both groups, but females with T1D started from a higher baseline. In T1D, HRs were significantly increased for any angiopathy in individuals with obesity (adj HR 1.37 (CI 1.14-1.64)), and for retinopathy; adj HRs (CIs): overweight; 1.15 (1.02-1.29), obesity; 1.30 (1.08-1.56).Conclusions: Females with T1D have increasing BMI overtime and are heavier than females without T1D. Overweight and obesity are by themselves risk factors for angiopathy.

Franko, Mikael AnderssonKarolinska Institutet (författare)
Lindholm Olinder, Anna,PhD,1960-Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden.(Swepub:uu)annli614 (författare)
Nystrom, ThomasKarolinska Institutet (författare)
Persson, MartinaKarolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden. (författare)
Karolinska InstitutetKarolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden. (creator_code:org_t)

Ingår i:Diabetes Research and Clinical Practice: Elsevier BV2040168-82271872-8227

Av författaren/redakt...: Haas, Josephine; Franko, Mikael A ...; Lindholm Olinder ...; Nystrom, Thomas; Persson, Martina

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