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- Mälberg, JohanUppsala universitet,Anestesiologi och intensivvård (författare)
Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
- Springer,2023
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- LIBRIS-ID:oai:DiVA.org:uu-515832
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-515832URI
- https://doi.org/10.1186/s40635-023-00559-7DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- BACKGROUND: Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or during a short pause after every 30 chest compressions (30:2). There is limited knowledge of how ventilation is delivered if it effects the hemodynamics and if it plays a role in the occurrence of lung injuries. The aim of this study was to compare ventilation parameters, hemodynamics, blood gases and lung injuries during experimental CPR given with CCC and 30:2 in a porcine model.METHODS: Sixteen pigs weighing approximately 33 kg were randomized to either receive CPR with CCC or 30:2. Ventricular fibrillation was induced by passing an electrical current through the heart. CPR was started after 3 min and given for 20 min. Chest compressions were provided mechanically with a chest compression device and ventilations were delivered manually with a self-inflating bag and 12 l/min of oxygen. During the experiment, ventilation parameters and hemodynamics were sampled continuously, and arterial blood gases were taken every five minutes. After euthanasia and cessation of CPR, the lungs and heart were removed in block and visually examined followed by sampling of lung tissue which were examined using microscopy.RESULTS: In the CCC group and the 30:2 group, peak inspiratory pressure (PIP) was 58.6 and 35.1 cmH2O (p < 0.001), minute volume (MV) 2189.6 and 1267.1 ml (p < 0.001), peak expired carbon dioxide (PECO2) 28.6 and 39.4 mmHg (p = 0.020), partial pressure of carbon dioxide (PaCO2) 50.2 and 61.1 mmHg (p = 0.013) and pH 7.3 and 7.2 (p = 0.029), respectively. Central venous pressure (CVP) decreased more over time in the 30:2 group (p = 0.023). All lungs were injured, but there were no differences between the groups.CONCLUSIONS: Ventilation during CCC resulted in a higher PIP, MV and pH and lower PECO2 and PaCO2, showing that ventilation mode during CPR can affect ventilation parameters and blood gases.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
- Animal model
- Cardiac arrest
- Cardiopulmonary resuscitation
- Lung injuries
- Ventilation
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Marchesi, Silvia (författare)
- Spangler, DouglasUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)dousp651 (författare)
- Hadziosmanovic, NerminUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)nerha973 (författare)
- Smekal, David,1971-Uppsala universitet,Anestesiologi och intensivvård(Swepub:uu)davsm531 (författare)
- Rubertsson, StenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)stenrube (författare)
- Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Intensive Care Medicine Experimental: Springer11:12197-425X
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