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Sökning: onr:"swepub:oai:DiVA.org:uu-516556" > Ghrelin Action in t...

Ghrelin Action in the PVH of Male Mice : Accessibility, Neuronal Targets, and CRH Neurons Activation

Fernandez, Gimena (författare)
Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.
De Francesco, Pablo N. (författare)
Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.
Cornejo, Maria P. (författare)
Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.
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Cabral, Agustina (författare)
Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.
Aguggia, Julieta P. (författare)
Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.
Duque, Victor J. (författare)
Univ Fed Sao Paulo UNIFESP, Dept Biophys, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil.
Sayar, Nilufer (författare)
Univ Iowa, Iowa Neurosci Inst, Carver Coll Med, Dept Neurosci & Pharmacol, Iowa City, IA 52242 USA.;Univ Iowa, Fraternal Order Eagles Diabet Res Ctr FOEDRC, Iowa City, IA 52242 USA.
Cantel, Sonia (författare)
Univ Montpellier, Inst Biomol Max Mousseron, CNRS, ENSCM, F-34293 Montpellier 5, France.
Burgos, Juan, I (författare)
Consejo Nacl Invest Cient & Tecn, Ctr Invest Cardiovasc Dr Horacio Eugenio Cingolani, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, RA-1900 La Plata, Buenos Aires, Argentina.
Fehrentz, Jean-Alain (författare)
Univ Montpellier, Inst Biomol Max Mousseron, CNRS, ENSCM, F-34293 Montpellier 5, France.
Rorato, Rodrigo (författare)
Univ Fed Sao Paulo UNIFESP, Dept Biophys, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil.
Atasoy, Deniz (författare)
Mecawi, Andre S. (författare)
Univ Fed Sao Paulo UNIFESP, Dept Biophys, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil.
Perello, Mario (författare)
Uppsala universitet,Funktionell farmakologi och neurovetenskap,Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina.;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina.;Multidisciplinary Inst Cell Biol, Lab Neurophysiol, Calle 526 S-N Entre 10 & 11-POB 403, RA-1900 La Plata, Buenos Aires, Argentina.
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Natl Univ Plata, Multidisciplinary Inst Cell Biol IMBICE, Argentine Res Council CONICET, Lab Neurophysiol, RA-1900 La Plata, Buenos Aires, Argentina;Natl Univ Plata, Sci Res Commiss, Prov Buenos Aires CIC PBA, RA-1900 La Plata, Buenos Aires, Argentina. Univ Fed Sao Paulo UNIFESP, Dept Biophys, Escola Paulista Med, BR-04023062 Sao Paulo, Brazil. (creator_code:org_t)
Endocrine Society, 2023
2023
Engelska.
Ingår i: Endocrinology. - : Endocrine Society. - 0013-7227 .- 1945-7170. ; 164:11
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The hormone ghrelin displays several well-characterized functions, including some with pharmaceutical interest. The receptor for ghrelin, the growth hormone secretagogue receptor (GHSR), is expressed in the hypothalamic paraventricular nucleus (PVH), a critical hub for the integration of metabolic, neuroendocrine, autonomic, and behavioral functions. Here, we performed a neuroanatomical and functional characterization of the neuronal types mediating ghrelin actions in the PVH of male mice. We found that fluorescent ghrelin mainly labels PVH neurons immunoreactive for nitric oxide synthase 1 (NOS1), which catalyze the production of nitric oxide [NO]). Centrally injected ghrelin increases c-Fos in NOS1 PVH neurons and NOS1 phosphorylation in the PVH. We also found that a high dose of systemically injected ghrelin increases the ghrelin level in the cerebrospinal fluid and in the periventricular PVH, and induces c-Fos in NOS1 PVH neurons. Such a high dose of systemically injected ghrelin activates a subset of NOS1 PVH neurons, which do not express oxytocin, via an arcuate nucleus-independent mechanism. Finally, we found that pharmacological inhibition of NO production fully abrogates ghrelin-induced increase of calcium concentration in corticotropin-releasing hormone neurons of the PVH whereas it partially impairs ghrelin-induced increase of plasma glucocorticoid levels. Thus, plasma ghrelin can directly target a subset of NO-producing neurons of the PVH that is involved in ghrelin-induced activation of the hypothalamic-pituitary-adrenal neuroendocrine axis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

GHSR
hypothalamus
PVN
stress
CRF
HPA axis

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