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Acyl ghrelin increa...
Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure
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- Erhardsson, Mikael (författare)
- Karolinska Institute
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- Faxén, Ulrika L (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Venkateshvaran, Ashwin (författare)
- Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital
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- Hage, Camilla (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Pironti, Gianluigi (författare)
- Karolinska Institute,Karolinska Institutet
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- Thorvaldsen, Tonje (författare)
- Karolinska Institute,Karolinska University Hospital
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- Webb, Dominic-Luc (författare)
- Uppsala University,Uppsala universitet,Gastroenterologi/hepatologi,Gastroenterology and Hepatology
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- Hellström, Per M., 1954- (författare)
- Uppsala University,Uppsala universitet,Gastroenterologi/hepatologi,Gastroenterology and Hepatology
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- Andersson, Daniel C (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Ståhlberg, Marcus (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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- Lund, Lars H (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822.
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- AIM: Acyl ghrelin increases cardiac output (CO) in heart failure with reduced ejection fraction (HFrEF). This could impair the right ventricular-pulmonary arterial coupling (RVPAC), both through an increased venous return and right ventricular afterload. We aim to investigate if acyl ghrelin increases CO with or without worsening the right-sided haemodynamics in HFrEF assessed by RVPAC.METHODS AND RESULTS: The Karolinska Acyl ghrelin Trial was a randomized double-blind placebo-controlled trial of acyl ghrelin versus placebo (120-min intravenous infusion) in HFrEF. RVPAC was assessed echocardiographically at baseline and 120 min. ANOVA was used for difference in change between acyl ghrelin versus placebo, adjusted for baseline values. Of the 30 randomized patients, 22 had available RVPAC (acyl ghrelin n = 12, placebo n = 10). Despite a 15% increase in CO in the acyl ghrelin group (from 4.0 (3.5-4.6) to 4.6 (3.9-6.1) L/min, P = 0.003), RVPAC remained unchanged; 5.9 (5.3-7.6) to 6.3 (4.8-7.5) mm·(m/s)-1 , P = 0.372, while RVPAC was reduced in the placebo group, 5.2 (4.3-6.4) to 4.8 (4.2-5.8) mm·(m/s)-1 , P = 0.035. Comparing change between groups, CO increased in the acyl ghrelin group versus placebo (P = 0.036) while RVPAC and the right ventricular pressure gradient remained unchanged.CONCLUSION: Treatment with acyl ghrelin increases CO while preserving or even improving RVPAC in HFrEF, possibly due to increased contractility, reduced PVR and/or reduced left sided filling pressures. These potential effects strengthen the role of acyl ghrelin therapy in HFrEF with right ventricular failure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Acyl ghrelin
- Heart failure
- Inotrope
- Cardiology
- Kardiologi
- Acyl ghrelin
- Heart failure
- Inotrope
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Erhardsson, Mika ...
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Faxén, Ulrika L
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Venkateshvaran, ...
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Hage, Camilla
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Pironti, Gianlui ...
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Thorvaldsen, Ton ...
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Webb, Dominic-Lu ...
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Hellström, Per M ...
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Andersson, Danie ...
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Ståhlberg, Marcu ...
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Lund, Lars H
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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ESC Heart Failur ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet