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Comparative genomi...
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
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- Moon, Katherine L. (författare)
- Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA, USA.;Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA, USA.
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- Huson, Heather J. (författare)
- Department of Animal Sciences, Cornell University College of Agriculture and Life Sciences, Ithaca, NY 14853, USA.
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- Morrill, Kathleen (författare)
- Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01655, USA.;Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA 01655, USA.;Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Wang, Ming-Shan (författare)
- Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA, USA.;Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA, USA.
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- Li, Xue (författare)
- Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01655, USA.;Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA 01655, USA.;Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Srikanth, Krishnamoorthy (författare)
- Department of Animal Sciences, Cornell University College of Agriculture and Life Sciences, Ithaca, NY 14853, USA.
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- Lindblad-Toh, Kerstin (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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- Svenson, Gavin J. (författare)
- Cleveland Museum of Natural History, Cleveland, OH 44106, USA.
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- Karlsson, Elinor K. (författare)
- Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01655, USA.;Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA 01655, USA.
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- Shapiro, Beth (författare)
- Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA, USA.;Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA, USA.
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Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA, USA;Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA, USA. Department of Animal Sciences, Cornell University College of Agriculture and Life Sciences, Ithaca, NY 14853, USA. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2023
- 2023
- Engelska.
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 380:6643
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of his diverse ancestry with the eponymous Siberian husky breed. Balto's genotype predicts a combination of coat features atypical for modern sled dog breeds, and a slightly smaller stature. He had enhanced starch digestion compared with Greenland sled dogs and a compendium of derived homozygous coding variants at constrained positions in genes connected to bone and skin development. We propose that Balto's population of origin, which was less inbred and genetically healthier than that of modern breeds, was adapted to the extreme environment of 1920s Alaska.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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Moon, Katherine ...
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Huson, Heather J ...
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Morrill, Kathlee ...
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Wang, Ming-Shan
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Li, Xue
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Srikanth, Krishn ...
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visa fler...
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Lindblad-Toh, Ke ...
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Svenson, Gavin J ...
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Karlsson, Elinor ...
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Shapiro, Beth
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