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CD49f (alpha 6 inte...
CD49f (alpha 6 integrin) and CD66a (BGP) are specifically induced by retinoids during human monocytic differentiation
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- Botling, Johan (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Öberg, Fredrik (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Nilsson, Kenneth (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- 1995
- 1995
- Engelska.
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Ingår i: Leukemia. - 0887-6924 .- 1476-5551. ; 9:12, s. 2034-41
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Retinoic acid (RA) and 1,25(OH)2-cholecalciferol (VitD3) are potent regulators of normal and malignant myeloid cells. In the human monoblast cell line U-937 they induce terminal differentiation, and the resulting phenotypes display both common and distinct, inducer-specific, properties. This paper shows that in U-937 cells the two retinoids, all-trans and 9-cis RA, induced the expression of CD49f (alpha 6 integrin subunit) and CD66a (biliary glycoprotein, BGP) mRNA and protein. In contrast, expression of CD49f and CD66a was not found in untreated or VitD3-induced cells. Cytokine-induced modulation of CD49f and CD66a expression was restricted to the retinoid-induced U-937 cells. The retinoid specific induction of CD49f and CD66a was confirmed in the related monoblastic cell line THP-1. Human blood monocytes and the monocytic cell line Mono Mac 6 responded poorly to RA, with respect to the regulation of CD49f and CD66a expression, indicating that early monocytic precursors were targets for the retinoid-specific regulation. Thus, the expression of CD49f and CD66a is developmentally regulated and specifically induced by all-trans and 9-cis Ra in human monocytic cells.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Leukemia
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