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Pre-prandial plasma...
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Andreoli, María FUppsala universitet,Funktionell farmakologi och neurovetenskap,Instituto de Desarrollo e Investigaciones Pediátricas (IDIP), HIAEP Sor María Ludovica de la Plata, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC-PBA), Calle 63 # 1069, La Plata, Buenos Aires, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), La Plata, Argentina. mfandreoli@fbcb.unl.edu.ar.
(författare)
Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner.
- Artikel/kapitelEngelska2023
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2023
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2023
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LIBRIS-ID:oai:DiVA.org:uu-519433
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519433URI
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https://doi.org/10.1007/s00394-023-03304-8DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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PURPOSE: The liver-expressed antimicrobial peptide 2 (LEAP2) is a newly recognized peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the effects of ghrelin and displaying ghrelin-independent actions. Since the implications of LEAP2 are beginning to be elucidated, we investigated if plasma LEAP2 concentration varies with feeding status or sex and whether it is associated with glucose metabolism and appetite sensations.METHODS: We performed a single test meal study, in which plasma concentrations of LEAP2, ghrelin, insulin and glucose as well as visual analogue scales for hunger, desire to eat, prospective food consumption, fullness were assessed before and 60 min after breakfast in 44 participants (n = 21 females) with normal weight (NW) or overweight/obesity (OW/OB).RESULTS: Pre-prandial plasma LEAP2 concentration was ~ 1.6-fold higher whereas ghrelin was ~ 2.0-fold lower in individuals with OW/OB (p < 0.001) independently of sex. After adjusting for body mass index (BMI) and sex, pre-prandial plasma LEAP2 concentration displayed a direct relationship with BMI (β: 0.09; 95%CI: 0.05, 0.13; p < 0.001), fat mass (β: 0.05; 95%CI: 0.01, 0.09; p = 0.010) and glycemia (β: 0.24; 95%CI: 0.05, 0.43; p = 0.021), whereas plasma ghrelin concentration displayed an inverse relationship with BMI and fat mass but not with glycemia. Postprandial plasma LEAP2 concentration increased ~ 58% in females with OW/OB (p = 0.045) but not in females with NW or in males. Pre-prandial plasma LEAP2 concentration displayed an inverse relationship with hunger score (β: - 11.16; 95% CI: - 18.52, - 3.79; p = 0.004), in a BMI-, sex- and ghrelin-independent manner.CONCLUSIONS: LEAP2 emerges as a key hormone implicated in the regulation of metabolism and appetite in humans.TRIAL REGISTRATION: The study was retrospectively registered in clinicaltrials.gov (April 2023).CLINICALTRIALS: gov Identifier: NCT05815641.
Ämnesord och genrebeteckningar
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Appetite sensations
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Ghrelin
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Hunger
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Insulin resistance
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LEAP2
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Obesity
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fittipaldi, Antonela S
(författare)
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Castrogiovanni, Daniel
(författare)
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De Francesco, Pablo N
(författare)
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Valdivia, Spring
(författare)
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Heredia, Florencia
(författare)
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Ribet-Travers, Carole
(författare)
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Mendez, Ignacio
(författare)
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Fasano, María V
(författare)
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Schiöth, Helgi B.Uppsala universitet,Schiöth: Funktionell farmakologi(Swepub:uu)helgschi
(författare)
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Doi, Suhail A
(författare)
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Habib, Abdella M
(författare)
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Perello, Mario
(författare)
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Uppsala universitetFunktionell farmakologi och neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Nutrition1436-62071436-6215
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Andreoli, María ...
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Fittipaldi, Anto ...
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Castrogiovanni, ...
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De Francesco, Pa ...
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Valdivia, Spring
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Heredia, Florenc ...
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visa fler...
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Ribet-Travers, C ...
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Mendez, Ignacio
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Fasano, María V
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Schiöth, Helgi B ...
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Doi, Suhail A
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Habib, Abdella M
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Perello, Mario
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Uppsala universitet