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Coadministered pneu...
Coadministered pneumococcal conjugate vaccine decreases immune response to hepatitis A vaccine : a randomized controlled trial
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- Riekkinen, Marianna (författare)
- Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Inflammat Ctr, Dept Infect Dis, Helsinki, Finland.;Univ Helsinki, Human Microbiome Res Unit, Helsinki, Finland.;Aava Med Ctr, Travel Clin, Helsinki, Finland.
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- Pakkanen, Sari H. (författare)
- Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Human Microbiome Res Unit, Helsinki, Finland.
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- Hutse, Veronik (författare)
- Sciensano Lab, Natl Reference Ctr Hepatitis Viruses, Infect Dis Humans, Brussels, Belgium.
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- Roukaerts, Inge (författare)
- Sciensano Lab, Natl Reference Ctr Hepatitis Viruses, Infect Dis Humans, Brussels, Belgium.
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- Ollgren, Jukka (författare)
- Finnish Inst Hlth & Welf THL, Infect Dis Control & Vaccinat Unit, Helsinki, Finland.
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- Kayhty, Helena (författare)
- Finnish Inst Hlth & Welf THL, Infect Dis Control & Vaccinat Unit, Helsinki, Finland.
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- Herzog, Christian (författare)
- Swiss Trop & Publ Hlth Inst, Allschwil, Switzerland.;Univ Basel, Basel, Switzerland.
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- Rombo, Lars (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Zoonosis Sci Ctr
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- Kantele, Anu (författare)
- Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Inflammat Ctr, Dept Infect Dis, Helsinki, Finland.;Univ Helsinki, Human Microbiome Res Unit, Helsinki, Finland.;Aava Med Ctr, Travel Clin, Helsinki, Finland.;Sormland Cty Council, Clin Res Ctr, Eskilstuna, Sweden.;Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Biomedicum 1,4th Floor,POB 700, FI-00029 Helsinki, Finland.;Helsinki Univ Hosp, Biomedicum 1,4th Floor,POB 700, FI-00029 Helsinki, Finland.
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Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Inflammat Ctr, Dept Infect Dis, Helsinki, Finland.;Univ Helsinki, Human Microbiome Res Unit, Helsinki, Finland.;Aava Med Ctr, Travel Clin, Helsinki, Finland. Univ Helsinki, Meilahti Vaccine Res Ctr, MeVac, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Human Microbiome Res Unit, Helsinki, Finland. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Clinical Microbiology and Infection. - : Elsevier. - 1198-743X .- 1469-0691. ; 29:12, s. 1553-1560
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- Objectives: We explored the influence of coadministration on safety and immunogenicity of the most common travellers' vaccine hepatitis A (HepA) and the pneumococcal conjugate vaccine (PCV) increasingly used both at home and before travel.Methods: Volunteers aged >= 18 years (n = 305) were randomly assigned 1:1:1 into three groups receiving: 13-valent PCV (PCV13) + HepA, PCV13, or HepA. Anti-pneumococcal IgG concentrations, opsonophagocytic activity (OPA) titres, and total hepatitis A antibody (anti-HAV) concentrations were measured before and 28 +/- 3 days after vaccination. Adverse events (AEs) were recorded over 4 weeks.Results: After vaccination, the anti-HAV geometric mean concentration was significantly lower in the PCV13+HepA than the HepA group: 34.47 mIU/mL (95% CI: 26.42-44.97 mIU/mL) versus 72.94 mIU/mL (95% CI: 55.01-96.72 mIU/mL), p < 0.001. Anti-HAV >= 10 mIU/mL considered protective was reached by 71 of 85 (83.5%) in the PCV13+HepA group versus 76 of 79 (96.2%) in the HepA group, p 0.008. The increases in anti-pneumococcal IgG and OPA levels were comparable in the PCV13+HepA and PCV13 groups, apart from a bigger rise in the PCV13+HepA group for serotype 3 (one-way ANOVA: serotype 3 IgG p 0.010, OPA p 0.002). AEs proved more frequent among those receiving PCV13 than HepA, but simultaneous administration did not increase the rates: >= one AE was reported by 45 of 56 (80.4%) PCV13, 43 of 54 (79.6%) PCV13+HepA, and 25 of 53 (47.2%) HepA recipients providing structured AE data.Discussion: Coadministration of HepA and PCV13 did not cause safety concerns, nor did it impact the patients' response to PCV13, apart from serotype 3. However, coadministered PCV13 significantly impaired antibody responses to HepA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Antibody
- Coadministration
- Hepatitis A
- Hepatitis A vaccine
- Immune interference
- Immunogenicity
- Pneumococcal conjugate vaccine
- Pneumococcus
- Travel
- Vaccination
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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