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Comparison of quant...
Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
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- Sousa, Joao M., 1989- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ, Uppsala Univ Hosp, Dept Surg Sci, PET Ctr, S-75185 Uppsala, Sweden.
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- Appel, Lieuwe (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden.
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- Engstrom, Mathias (författare)
- Collect Minds Radiol AB, Taby, Sweden.
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- Nyholm, Dag, Professor, 1974- (författare)
- Uppsala universitet,Neurologi,Uppsala Univ Hosp, Dept Neurol, Uppsala, Sweden.
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden.;Antaros Med AB, BioVenture Hub, Mölndal, Sweden.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Physica medica (Testo stampato). - : Elsevier. - 1120-1797 .- 1724-191X. ; 117
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PET/MR systems demanded great efforts for accurate attenuation correction (AC) but differences in technology, geometry and hardware attenuation may also affect quantitative results. Dedicated PET systems using transmission-based AC are regarded as the gold standard for quantitative brain PET. The study aim was to investigate the agreement between quantitative PET outcomes from a PET/MR scanner against a stand-alone PET system.Nine patients with Parkinsonism underwent two 80-min dynamic PET scans with the dopamine transporter ligand [11C]PE2I. Images were reconstructed with resolution-matched settings using 68Ge-transmission (standalone PET), and zero-echo-time MR (PET/MR) scans for AC. Non-displaceable binding potential (BPND) and relative delivery (R1) were evaluated using volumes of interest and voxel-wise analysis.Correlations between systems were high (r >= 0.85) for both quantitative outcome parameters in all brain regions. Striatal BPND was significantly lower on PET/MR than on stand-alone PET (-7%). R1 was significantly overestimated in posterior cortical regions (9%) and underestimated in striatal (-9%) and limbic areas (-6%). The voxel-wise evaluation revealed that the MR-safe headphones caused a negative bias in both parametric BPND and R1 images. Additionally, a significant positive bias of R1 was found in the auditory cortex, most likely due to the acoustic background noise during MR imaging. The relative bias of the quantitative [11C]PE2I PET data acquired from a SIGNA PET/MR system was in the same order as the expected test-retest reproducibility of [11C]PE2I BPND and R1, compared to a stand-alone ECAT PET scanner. MR headphones and background noise are potential sources of error in functional PET/MR studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Positron emission tomography
- Dopamine transporter
- Cerebral blood flow
- PET quantification
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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