Sökning: onr:"swepub:oai:DiVA.org:uu-520380" >
Colicins and T6SS-b...
Colicins and T6SS-based competition systems enhance enterotoxigenic E. coli (ETEC) competitiveness
-
- Kjellin, Jonas (författare)
- Uppsala universitet,Mikrobiologi och immunologi
-
- Lee, Danna (författare)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
-
- Steinsland, Hans (författare)
- Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, CISMAC, Bergen, Norway.;Univ Bergen, Dept Biomed, Bergen, Norway.
-
visa fler...
-
- Dwane, Rachel (författare)
- Uppsala universitet,Mikrobiologi och immunologi
-
- Barth Vedoy, Oda (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.
-
- Hanevik, Kurt (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Natl Ctr Trop Infect Dis, Dept Med, Bergen, Norway.
-
- Koskiniemi, Sanna, 1980- (författare)
- Uppsala universitet,Mikrobiologi och immunologi
-
visa färre...
-
(creator_code:org_t)
- Taylor & Francis, 2024
- 2024
- Engelska.
-
Ingår i: Gut microbes. - : Taylor & Francis. - 1949-0976 .- 1949-0984. ; 16:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Diarrheal diseases are still a significant problem for humankind, causing approximately half a million deaths annually. To cause diarrhea, enteric bacterial pathogens must first colonize the gut, which is a niche occupied by the normal bacterial microbiota. Therefore, the ability of pathogenic bacteria to inhibit the growth of other bacteria can facilitate the colonization process. Although enterotoxigenic Escherichia coli (ETEC) is one of the major causative agents of diarrheal diseases, little is known about the competition systems found in and used by ETEC and how they contribute to the ability of ETEC to colonize a host. Here, we collected a set of 94 fully assembled ETEC genomes by performing whole-genome sequencing and mining the NCBI RefSeq database. Using this set, we performed a comprehensive search for delivered bacterial toxins and investi-gated how these toxins contribute to ETEC competitiveness in vitro. We found that type VI secretion systems (T6SS) were widespread among ETEC (n = 47). In addition, several closely related ETEC strains were found to encode Colicin Ia and T6SS (n = 8). These toxins provide ETEC compe-titive advantages during in vitro competition against other E. coli, suggesting that the role of T6SS as well as colicins in ETEC biology has until now been underappreciated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- ETEC
- colicin
- type VI secretion
- competitive advantage
- genome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas