Sökning: onr:"swepub:oai:DiVA.org:uu-521808" >
Morbidity and Morta...
Morbidity and Mortality Associated With Heart Failure in Acute Coronary Syndrome : A Pooled Analysis of 4 Clinical Trials
-
- Goodwin, Nathan P. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
- Clare, Robert M. (författare)
- Duke Univ, Sch Med, Durham, NC USA.
-
- Harrington, Josephine L. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
visa fler...
-
- Badjatiya, Anish (författare)
- Texas Heart Inst, Baylor Coll Med, Dept Med, Div Cardiol, Houston, TX USA.
-
- Wojdyla, Daniel M. (författare)
- Duke Univ, Sch Med, Durham, NC USA.
-
- Udell, Jacob A. (författare)
- Womens Coll Hosp, Dept Med, Cardiovasc Div, Toronto, ON, Canada.;Univ Toronto, Toronto Gen Hosp, Peter Munk Cardiac Ctr, Toronto, ON, Canada.
-
- Butler, Javed (författare)
- Univ Mississippi, Dept Med, Jackson, MS USA.
-
- Januzzi Jr, James L. (författare)
- Massachusetts Gen Hosp & Cardiac Trials, Baim Inst Clin Res, Div Cardiol, Boston, MA USA.
-
- Parikh, Puja B. (författare)
- SUNY Stony Brook, Med Ctr, Div Cardiovasc Med, Stony Brook, NY USA.
-
- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Alexander, John H. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.;Duke Univ, Sch Med, Durham, NC USA.
-
- Lopes, Renato D. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Ohman, E. Magnus (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
- Hernandez, Adrian F. (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
- Jones, W. Schuyler (författare)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
-
visa färre...
-
Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA Duke Univ, Sch Med, Durham, NC USA. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
-
Ingår i: Journal of Cardiac Failure. - : Elsevier. - 1071-9164 .- 1532-8414. ; 29:12, s. 1603-1614
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Heart failure (HF) may complicate acute coronary syndrome (ACS) and is associ-ated with a high burden of short-and long-term morbidity and mortality. Only limited data regarding future ischemic events and rehospitalization are available for patients who suffer HF before or during ACS.Methods: A secondary analysis of 4 large ACS trials (PLATO, APPRAISE-2, TRACER, and TRIL-OGY ACS) using Cox proportional hazards models was performed to investigate the associa-tion of HF status (no HF, chronic HF, de novo HF) at presentation for ACS with all-cause and cardiovascular death, major adverse cardiovascular event (MACE ), myocardial infarction, stroke, and hospitalization for heart failure (HHF) by 1 year. Cumulative incidence plots are presented at 30 days and 1 year.Results: A total of 11.1% of the 47,474 patients presenting with ACS presented with evidence of acute HF, 55.0% of whom presented with de novo HF. Patients with chronic HF presented with evidence of acute HF at a higher rate than those with no previous HF (40.3% vs 6.9%). Compared to those without HF, those with chronic and de novo HF had higher rates of all-cause mortality (adjusted hazard ratio [aHR] 2.01, 95% confidence interval [CI] 1.72-2.34 and aHR 1.47, 95% CI1.15-1.88, respectively), MACE (aHR 1.47, 95% CI1.31-1-.66 and aHR 1.38, 95% CI1.12-1.69), and HHF (aHR 2.29, 95% CI2.02-2.61 and aHR 1.48, 95% CI 1.20-1.82) at 1 year.Conclusion: In this large cohort of patients with ACS, both prior and de novo HF complicating ACS were associated with significantly higher risk-adjusted rates of death, ischemic events and HHF at 30 days and 1 year. Further studies examining the association between HF and out-comes in this high-risk population are warranted, especially given the advent of more contem-porary HF therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Acute coronary syndrome
- heart failure
- ischemic events
- hospitalization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Goodwin, Nathan ...
-
Clare, Robert M.
-
Harrington, Jose ...
-
Badjatiya, Anish
-
Wojdyla, Daniel ...
-
Udell, Jacob A.
-
visa fler...
-
Butler, Javed
-
Januzzi Jr, Jame ...
-
Parikh, Puja B.
-
James, Stefan, 1 ...
-
Alexander, John ...
-
Lopes, Renato D.
-
Wallentin, Lars, ...
-
Ohman, E. Magnus
-
Hernandez, Adria ...
-
Jones, W. Schuyl ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of Cardi ...
- Av lärosätet
-
Uppsala universitet