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Comparison between ...
Comparison between ticagrelor and clopidogrel in myocardial infarction patients with high bleeding risk
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- Tjerkaski, Jonathan (författare)
- Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, S-18257 Danderyd, Stockholm, Sweden.,Danderyd Hospital
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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- Alfredsson, Joakim (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- James, Stefan, 1964- (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Lindahl, Bertil, 1957- (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Mohammad, Moman Aladdin (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Omerovic, Elmir (författare)
- Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Venetsanos, Dimitrios (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Szummer, Karolina (författare)
- Karolinska Institute
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Karolinska Inst, Danderyd Univ Hosp, Dept Clin Sci, S-18257 Danderyd, Stockholm, Sweden Danderyd Hospital (creator_code:org_t)
- Oxford University Press, 2023
- 2023
- Engelska.
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Ingår i: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press. - 2055-6837 .- 2055-6845. ; 9:7, s. 627-635
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Abstract
Ämnesord
Stäng
- Aims: Ticagrelor is associated with a lower risk of ischemic events than clopidogrel. However, it is uncertain whether the benefits of more intensive anti-ischemic therapy outweigh the risks of major bleeding in patients who have a high bleeding risk (HBR). Therefore, this study compared ticagrelor and clopidogrel in myocardial infarction (MI) patients with HBR.Methods and results: This study included all patients enrolled in the SWEDEHEART registry who were discharged with dual antiplatelet therapy using ticagrelor or clopidogrel following MI between 2010 and 2017. High bleeding risk was defined as a PRECISE-DAPT score & GE;25. Information on ischemic events, major bleeding, and mortality was obtained from national registries, with 365 days of follow-up. Additional outcomes include major adverse cardiovascular events (MACE), a composite of MI, stroke and all-cause mortality, and net adverse clinical events (NACE), a composite of MACE and bleeding. This study included 25 042 HBR patients, of whom 11 848 were treated with ticagrelor. Ticagrelor was associated with a lower risk of MI, stroke, and MACE, but a higher risk of bleeding compared to clopidogrel. There were no significant differences in mortality and NACE. Additionally, when examining the relationship between antiplatelet therapy and bleeding risk in 69 040 MI patients, we found no statistically significant interactions between the PRECISE-DAPT score and treatment effect.Conclusions: We observed no difference in NACE when comparing ticagrelor and clopidogrel in HBR patients. Moreover, we found no statistically significant interactions between bleeding risk and the comparative effectiveness of clopidogrel and ticagrelor in a larger population of MI patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Myocardial infarction
- Major bleeding
- Risk score
- Dual antiplatelet therapy
- Dual antiplatelet therapy
- Major bleeding
- Myocardial infarction
- Risk score
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Tjerkaski, Jonat ...
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Jernberg, Tomas
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Alfredsson, Joak ...
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Erlinge, David
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James, Stefan, 1 ...
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Lindahl, Bertil, ...
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Mohammad, Moman ...
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Omerovic, Elmir
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Venetsanos, Dimi ...
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Szummer, Karolin ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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European Heart J ...
- Av lärosätet
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Uppsala universitet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet