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Atypical (non‐V600E...
Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts
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- Österlund, Emerik (författare)
- Uppsala universitet,Cancerprecisionsmedicin,Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
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- Ristimäki, Ari (författare)
- Department of Pathology, HUSLAB, HUS Diagnostic Center Helsinki University Hospital Helsinki Finland;Faculty of Medicine, Applied Tumor Genomics Research Program, Research Programs Unit University of Helsinki Helsinki Finland
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- Mäkinen, Markus J. (författare)
- Department of Pathology Oulu University Hospital Oulu Finland;Translational Medicine Research Unit, Department of Pathology University of Oulu Oulu Finland;Medical Research Center Oulu Oulu Finland
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- Kytölä, Soili (författare)
- Department of Genetics, HUSLAB, HUS Diagnostic Center Helsinki University Hospital Helsinki Finland;Department of Genetics University of Helsinki Helsinki Finland
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- Kononen, Juha (författare)
- Departemnt of Oncology, Central hospital of Central Finland Jyväskylä Finland;Docrates hospital Helsinki Finland
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- Pfeiffer, Per (författare)
- Department of Oncology Odense University Hospital Odense Denmark;Department of Clinical Research University of Southern Denmark Odense Denmark
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- Soveri, Leena‐Maija (författare)
- Home Care, Geriatric Clinic and Palliative Care, Joint Municipal Authority for Health Care and Social Services in Keski‐Uusimaa Hyvinkää Finland;Department of Oncology Helsinki University Hospital Helsinki Finland
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- Keinänen, Mauri (författare)
- Department of Genetics, Fimlab Laboratories Tampere Finland
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- Sorbye, Halfdan (författare)
- Department of Oncology Haukeland University Hospital Bergen Norway;Department of Clinical Science University of Bergen Bergen Norway
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- Nunes, Luís, 1995- (författare)
- Uppsala universitet,Cancerprecisionsmedicin
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- Salminen, Tapio (författare)
- Department of Oncology Tampere University Hospital Tampere Finland;Department of Oncology University of Tampere Tampere Finland
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- Nieminen, Lasse (författare)
- Department of Pathology Tampere University Hospital Tampere Finland;Department of Pathology University of Tampere Tampere Finland
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- Uutela, Aki (författare)
- Department of Transplantation and Liver Surgery Helsinki University Hospital Helsinki Finland;Department of Surgery University of Helsinki Helsinki Finland;Department of Transplant and HPB Surgery, Royal Infirmary of Edinburgh Edinburgh UK
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- Halonen, Päivi (författare)
- Department of Oncology Helsinki University Hospital Helsinki Finland;Department of Oncology University of Helsinki Helsinki Finland
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- Ålgars, Annika (författare)
- Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland
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- Sundström, Jari (författare)
- Department of Pathology Turku University Hospital Turku Finland;Institute of Biomedicine University of Turku Turku Finland
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- Kallio, Raija (författare)
- Department of Oncology Oulu University Hospital Oulu Finland;Department of Oncology University of Oulu Oulu Finland
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- Ristamäki, Raija (författare)
- Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland
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- Lamminmäki, Annamarja (författare)
- Department of Oncology Kuopio University Hospital Kuopio Finland;Department of Medicine University of Eastern Finland Kuopio Finland
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- Stedt, Hanna (författare)
- Department of Oncology Kuopio University Hospital Kuopio Finland;Department of Medicine University of Eastern Finland Kuopio Finland
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- Heervä, Eetu (författare)
- Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland
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- Kuopio, Teijo (författare)
- Department of Pathology, Central Finland Hospital Nova Jyväskylä Finland;Department of Biological and Environmental Science University of Jyväskylä Jyväskylä Finland
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- Sjöblom, Tobias (författare)
- Uppsala universitet,Cancerprecisionsmedicin
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- Isoniemi, Helena (författare)
- Department of Transplantation and Liver Surgery Helsinki University Hospital Helsinki Finland;Department of Surgery University of Helsinki Helsinki Finland
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- Glimelius, Bengt (författare)
- Uppsala universitet,Cancerprecisionsmedicin
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- Osterlund, Pia (författare)
- Department of Oncology Tampere University Hospital Tampere Finland;Department of Oncology University of Tampere Tampere Finland;Department of Surgery University of Helsinki Helsinki Finland;Department of Transplant and HPB Surgery, Royal Infirmary of Edinburgh Edinburgh UK;Department of Gastrointestinal Oncology Karolinska Universitetssjukhuset Stockholm Sweden
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 154:3, s. 488-503
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, co-mutations and prognostic and predictive role. These were compared between mutational groups of mCRC patients collected from three Nordic population-based or real-world cohorts. Pathology of aBRAFmt was studied. The study included 1449 mCRC patients with 51 (3%) aBRAFmt, 182 (13%) BRAF-V600Emt, 456 (31%) RAS&BRAF wild-type (wt) and 760 (52%) RASmt tumours. aBRAFmt were seen in 2% of real-world and 4% of population-based cohorts. Twenty-six different aBRAFmt were detected, 11 (22%) class 2 (serrated adenocarcinoma in 2/9 tested), 32 (64%) class 3 (serrated in 15/25) and 4 (8%) unclassified. aBRAFmt patients were predominantly male, had more rectal primaries, less peritoneal metastases, deficient mismatch repair in one (2%), and better survival after metastasectomy (89% 5-year overall survival [OS]-rate) compared with BRAF-V600Emt. aBRAFmt and BRAF-V600Emt had poorer performance status and received fewer treatment lines than RAS&BRAFwt and RASmt. OS among aBRAFmt (median 14.4 months) was longer than for BRAF-V600Emt (11.2 months), but shorter than for RAS&BRAFwt (30.5 months) and RASmt (23.4 months). Addition of bevacizumab trended for better OS for the aBRAFmt. Nine patients with aBRAFmt received cetuximab/panitumumab without response. aBRAFmt represents a distinct subgroup differing from other RAS/BRAF groups, with serrated adenocarcinoma in only half. OS for patients with aBRAFmt tumours was slightly better than for BRAF-V600Emt, but worse than for RASmt and RAS&BRAFwt. aBRAFmt should not be a contraindication for metastasectomy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Österlund, Emeri ...
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Ristimäki, Ari
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Mäkinen, Markus ...
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Kytölä, Soili
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Kononen, Juha
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Pfeiffer, Per
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visa fler...
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Soveri, Leena‐Ma ...
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Keinänen, Mauri
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Sorbye, Halfdan
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Nunes, Luís, 199 ...
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Salminen, Tapio
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Nieminen, Lasse
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Uutela, Aki
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Halonen, Päivi
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Ålgars, Annika
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Sundström, Jari
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Kallio, Raija
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Ristamäki, Raija
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Lamminmäki, Anna ...
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Stedt, Hanna
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Heervä, Eetu
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Kuopio, Teijo
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Sjöblom, Tobias
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Isoniemi, Helena
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Glimelius, Bengt
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Osterlund, Pia
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Uppsala universitet
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Karolinska Institutet