Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

Österlund, Emerik (författare): Uppsala universitet,Cancerprecisionsmedicin,Department of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland

Ristimäki, Ari (författare): Department of Pathology, HUSLAB, HUS Diagnostic Center Helsinki University Hospital Helsinki Finland;Faculty of Medicine, Applied Tumor Genomics Research Program, Research Programs Unit University of Helsinki Helsinki Finland

Mäkinen, Markus J. (författare): Department of Pathology Oulu University Hospital Oulu Finland;Translational Medicine Research Unit, Department of Pathology University of Oulu Oulu Finland;Medical Research Center Oulu Oulu Finland

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Kytölä, Soili (författare): Department of Genetics, HUSLAB, HUS Diagnostic Center Helsinki University Hospital Helsinki Finland;Department of Genetics University of Helsinki Helsinki Finland

Kononen, Juha (författare): Departemnt of Oncology, Central hospital of Central Finland Jyväskylä Finland;Docrates hospital Helsinki Finland

Pfeiffer, Per (författare): Department of Oncology Odense University Hospital Odense Denmark;Department of Clinical Research University of Southern Denmark Odense Denmark

Soveri, Leena‐Maija (författare): Home Care, Geriatric Clinic and Palliative Care, Joint Municipal Authority for Health Care and Social Services in Keski‐Uusimaa Hyvinkää Finland;Department of Oncology Helsinki University Hospital Helsinki Finland

Keinänen, Mauri (författare): Department of Genetics, Fimlab Laboratories Tampere Finland

Sorbye, Halfdan (författare): Department of Oncology Haukeland University Hospital Bergen Norway;Department of Clinical Science University of Bergen Bergen Norway

Nunes, Luís, 1995- (författare): Uppsala universitet,Cancerprecisionsmedicin

Salminen, Tapio (författare): Department of Oncology Tampere University Hospital Tampere Finland;Department of Oncology University of Tampere Tampere Finland

Nieminen, Lasse (författare): Department of Pathology Tampere University Hospital Tampere Finland;Department of Pathology University of Tampere Tampere Finland

Uutela, Aki (författare): Department of Transplantation and Liver Surgery Helsinki University Hospital Helsinki Finland;Department of Surgery University of Helsinki Helsinki Finland;Department of Transplant and HPB Surgery, Royal Infirmary of Edinburgh Edinburgh UK

Halonen, Päivi (författare): Department of Oncology Helsinki University Hospital Helsinki Finland;Department of Oncology University of Helsinki Helsinki Finland

Ålgars, Annika (författare): Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland

Sundström, Jari (författare): Department of Pathology Turku University Hospital Turku Finland;Institute of Biomedicine University of Turku Turku Finland

Kallio, Raija (författare): Department of Oncology Oulu University Hospital Oulu Finland;Department of Oncology University of Oulu Oulu Finland

Ristamäki, Raija (författare): Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland

Lamminmäki, Annamarja (författare): Department of Oncology Kuopio University Hospital Kuopio Finland;Department of Medicine University of Eastern Finland Kuopio Finland

Stedt, Hanna (författare): Department of Oncology Kuopio University Hospital Kuopio Finland;Department of Medicine University of Eastern Finland Kuopio Finland

Heervä, Eetu (författare): Department of Oncology Turku University Hospital Turku Finland;Department of Oncology University of Turku Turku Finland

Kuopio, Teijo (författare): Department of Pathology, Central Finland Hospital Nova Jyväskylä Finland;Department of Biological and Environmental Science University of Jyväskylä Jyväskylä Finland

Sjöblom, Tobias (författare): Uppsala universitet,Cancerprecisionsmedicin

Isoniemi, Helena (författare): Department of Transplantation and Liver Surgery Helsinki University Hospital Helsinki Finland;Department of Surgery University of Helsinki Helsinki Finland

Glimelius, Bengt (författare): Uppsala universitet,Cancerprecisionsmedicin

Osterlund, Pia (författare): Department of Oncology Tampere University Hospital Tampere Finland;Department of Oncology University of Tampere Tampere Finland;Department of Surgery University of Helsinki Helsinki Finland;Department of Transplant and HPB Surgery, Royal Infirmary of Edinburgh Edinburgh UK;Department of Gastrointestinal Oncology Karolinska Universitetssjukhuset Stockholm Sweden

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John Wiley & Sons, 2024
2024
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 154:3, s. 488-503

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BRAF-V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non-V600Emt, designated atypical BRAFmt (aBRAFmt) are rare, and little is known about their frequency, co-mutations and prognostic and predictive role. These were compared between mutational groups of mCRC patients collected from three Nordic population-based or real-world cohorts. Pathology of aBRAFmt was studied. The study included 1449 mCRC patients with 51 (3%) aBRAFmt, 182 (13%) BRAF-V600Emt, 456 (31%) RAS&BRAF wild-type (wt) and 760 (52%) RASmt tumours. aBRAFmt were seen in 2% of real-world and 4% of population-based cohorts. Twenty-six different aBRAFmt were detected, 11 (22%) class 2 (serrated adenocarcinoma in 2/9 tested), 32 (64%) class 3 (serrated in 15/25) and 4 (8%) unclassified. aBRAFmt patients were predominantly male, had more rectal primaries, less peritoneal metastases, deficient mismatch repair in one (2%), and better survival after metastasectomy (89% 5-year overall survival [OS]-rate) compared with BRAF-V600Emt. aBRAFmt and BRAF-V600Emt had poorer performance status and received fewer treatment lines than RAS&BRAFwt and RASmt. OS among aBRAFmt (median 14.4 months) was longer than for BRAF-V600Emt (11.2 months), but shorter than for RAS&BRAFwt (30.5 months) and RASmt (23.4 months). Addition of bevacizumab trended for better OS for the aBRAFmt. Nine patients with aBRAFmt received cetuximab/panitumumab without response. aBRAFmt represents a distinct subgroup differing from other RAS/BRAF groups, with serrated adenocarcinoma in only half. OS for patients with aBRAFmt tumours was slightly better than for BRAF-V600Emt, but worse than for RASmt and RAS&BRAFwt. aBRAFmt should not be a contraindication for metastasectomy.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts

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