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Ulva lactuca polysa...
Ulva lactuca polysaccharide inhibits hepatocellular carcinoma growth by induces the expression of CD5L and activates complement cascade
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- Xu, Jingxiang (författare)
- Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Peoples R China.
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- Liao, Wei (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
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- Yang, Shuxin (författare)
- Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Peoples R China.
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- Liu, Juan (författare)
- Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Peoples R China.
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- Jiang, Shiyue (författare)
- Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Peoples R China.
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- Liu, Yuanyuan (författare)
- Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
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- El-Seedi, Hesham R. (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Zhao, Chao (författare)
- Fujian Agr & Forestry Univ, Coll Marine Sci, Fuzhou 350002, Peoples R China.;Fujian Agr & Forestry Univ, State Key Lab Mariculture Breeding, Key Lab Marine Biotechnol Fujian Prov, Fuzhou 350002, Peoples R China.;15 Shangxiadian Rd, Fuzhou 350002, Peoples R China.
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Gannan Med Univ, Sch Basic Med, Ganzhou 341000, Peoples R China Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Journal of Functional Foods. - : Elsevier. - 1756-4646 .- 2214-9414. ; 112
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ulva polysaccharide (ULP) as main active ingredient of Ulva lactuca, has good pharmacological activity. This study further explored its anti-tumor mechanisms in hepatocellular carcinoma (HCC) with wet experiments and bioinformatic analyses. Results indicate that the differential proteins after ULP treatment are mainly enriched in immunomodulatory and complement pathways, among which the immune molecule CD5L and the key proteins of the membrane attack complex (MAC) are significantly upregulated, and the expression of MAC proteins are positively correlated with the expression of CD5L. Moreover, results from TIMER2.0 indicated that CD5L expression had positive correlation with CD8 + T cell infiltration in HCC, and single cell RNA-Seq analysis showed CD5L positive macrophage cells have higher expression of CFP, C1QA, C1QB, and C1QC, which are key molecular of complement cascades. Take together, the results suggest that ULP may exerts its anti-tumor activity by induces the expression of CD5L in HCC.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Ulva lactuca
- Hepatocellular carcinoma
- CD5L
- Complement cascade
- Anti-tumor activity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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