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  • Chen, Qiao SenKarolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden. (författare)

A machine learning based approach to identify carotid subclinical atherosclerosis endotypes

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • OXFORD UNIV PRESS,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-523327
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523327URI
  • https://doi.org/10.1093/cvr/cvad106DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153251802URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Aims To define endotypes of carotid subclinical atherosclerosis. Methods and results We integrated demographic, clinical, and molecular data (n = 124) with ultrasonographic carotid measurements from study participants in the IMPROVE cohort (n = 3340). We applied a neural network algorithm and hierarchical clustering to identify carotid atherosclerosis endotypes. A measure of carotid subclinical atherosclerosis, the c-IMTmean-max, was used to extract atherosclerosis-related features and SHapley Additive exPlanations (SHAP) to reveal endotypes. The association of endotypes with carotid ultrasonographic measurements at baseline, after 30 months, and with the 3-year atherosclerotic cardiovascular disease (ASCVD) risk was estimated by linear (& beta;, SE) and Cox [hazard ratio (HR), 95% confidence interval (CI)] regression models. Crude estimates were adjusted by common cardiovascular risk factors, and baseline ultrasonographic measures. Improvement in ASCVD risk prediction was evaluated by C-statistic and by net reclassification improvement with reference to SCORE2, c-IMTmean-max, and presence of carotid plaques. An ensemble stacking model was used to predict endotypes in an independent validation cohort, the PIVUS (n = 1061). We identified four endotypes able to differentiate carotid atherosclerosis risk profiles from mild (endotype 1) to severe (endotype 4). SHAP identified endotype-shared variables (age, biological sex, and systolic blood pressure) and endotype-specific biomarkers. In the IMPROVE, as compared to endotype 1, endotype 4 associated with the thickest c-IMT at baseline (& beta;, SE) 0.36 (0.014), the highest number of plaques 1.65 (0.075), the fastest c-IMT progression 0.06 (0.013), and the highest ASCVD risk (HR, 95% CI) (1.95, 1.18-3.23). Baseline and progression measures of carotid subclinical atherosclerosis and ASCVD risk were associated with the predicted endotypes in the PIVUS. Endotypes consistently improved measures of ASCVD risk discrimination and reclassification in both study populations. Conclusions We report four replicable subclinical carotid atherosclerosis-endotypes associated with progression of atherosclerosis and ASCVD risk in two independent populations. Our approach based on endotypes can be applied for precision medicine in ASCVD prevention.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bergman, OttoKarolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden. (författare)
  • Ziegler, LouiseKarolinska Inst, Danderyd Hosp, Div Med, Entrevagen 2, S-18288 Stockholm, Sweden.;Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Entrevagen 2, S-18288 Stockholm, Sweden. (författare)
  • Baldassarre, DamianoUniv Milan, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20133 Milan, Italy.;IRCCS, Ctr Cardiol Monzino, Via Carlo Parea 4, I-20138 Milan, Italy. (författare)
  • Veglia, FabrizioMaria Cecilia Hosp, GVM Care & Res, Via Corriera 1, I-48033 Cotignola, RA, Italy. (författare)
  • Tremoli, ElenaMaria Cecilia Hosp, GVM Care & Res, Via Corriera 1, I-48033 Cotignola, RA, Italy. (författare)
  • Strawbridge, Rona J.Karolinska Institutet,Karolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden.;Univ Glasgow, Inst Hlth & Wellbeing, Clarice Pears Bldg,90 Byres Rd, Glasgow G12 8TB, Scotland.;Hlth Data Res, Clarice Pears Bldg,90 Byres Rd, Glasgow, Scotland. (författare)
  • Gallo, AntonioSorbonne Univ, Hop Pitie Salpetriere, AP HP, Lipidol & Cardiovasc Prevent Unit,Dept Nutr,INSERM, 47 Blvd Hop, F-75013 Paris, France. (författare)
  • Pirro, MatteoUniv Perugia, Dept Med, Internal Med Angiol & Arteriosclerosis Dis, Piazzale Menghini 1, I-06129 Perugia, Italy. (författare)
  • Smit, Andries J.Univ Med Ctr Groningen, Dept Med, Groningen & Isala Clin Zwolle, Dokter Spanjaardweg 29B, NL-8025 BT Groningen, Netherlands. (författare)
  • Kurl, SudhirUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio Campus,Yliopistonranta 1 C,Canth Bldg,B Win, FI-70211 Kuopio, Finland. (författare)
  • Savonen, KaiKuopio Res Inst Exercise Med, Haapaniementie 16, Kuopio 70100, Finland.;Kuopio Univ Hosp, Sci Serv Ctr, Dept Clin Physiol & Nucl Med, Yliopsistonranta 1F, FI-70211 Kuopio, Finland. (författare)
  • Lind, LarsUppsala universitet,Science for Life Laboratory, SciLifeLab,Centrum för klinisk forskning, Gävleborg,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Klinisk nutrition och metabolism,Molekylär epidemiologi,Radiologi,Klinisk epidemiologi,Uppsala Univ, Dept Med Sci, Uppsala Sci Pk,Dag Hammarskjoldsv 10B, S-75237 Uppsala, Sweden.(Swepub:uu)larslind (författare)
  • Eriksson, PerKarolinska Institutet,Karolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden. (författare)
  • Gigante, BrunaKarolinska Institutet,Karolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden.;Danderyd Hosp, Dept Cardiol, Entrevagen 2, S-18288 Stockholm, Sweden. (författare)
  • Karolinska Inst, Dept Med Solna, Div Cardiovasc Med, Solnavagen 30, S-17164 Stockholm, Sweden.Karolinska Inst, Danderyd Hosp, Div Med, Entrevagen 2, S-18288 Stockholm, Sweden.;Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Entrevagen 2, S-18288 Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cardiovascular Research: OXFORD UNIV PRESS119:16, s. 2594-26060008-63631755-3245

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