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Mucosal and Plasma ...
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Nyström, NiklasUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
(författare)
Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease : Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
- Artikel/kapitelEngelska2023
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2022-10-11
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Oxford University Press,2023
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LIBRIS-ID:oai:DiVA.org:uu-524107
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524107URI
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https://doi.org/10.1093/ecco-jcc/jjac149DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101764URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:236219554URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155267848URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background and AimsTo advance the understanding of inflammatory bowel disease [IBD] pathophysiology, we compared the mucosal and plasma metabolomes between new-onset paediatric IBD patients and symptomatic non-IBD controls, and correlated plasma inflammation markers and disease characteristics with the altered metabolites.MethodsPaired colonic and ileal biopsies and plasma from 67 treatment-naïve children with incident Crohn’s disease [CD; n = 47], ulcerative colitis [UC; n = 9], and non-IBD controls [n = 11] were analysed using ultra-performance liquid chromatography-mass spectrometry [UPLC-MS/MS]. Inflammatory plasma proteins [n = 92] were assessed.ResultsThe metabolomes in inflamed mucosal biopsies differed between IBD patients and controls. In CD, mucosal levels of several lysophospholipids [lysophosphatidylcholines, lysophosphatidyletanolamines, lysophosphatidylinositols, and lysophosphatidylserines] were decreased, correlating with various plasma metabolites including amino acid analogues and N-acetylated compounds. In both CD and UC, mucosal sphingolipids, including ceramide [d18:2/24:1, d18:1/24:2], lactosyl-N-palmitoyl-sphingosine [d18:1/16:0], behenoyl sphingomyelin [d18:1/22:0], lignoceroyl sphingomyelin [d18:1/24:0], and/or sphingomyelin [d18:1/24:1, d18:2/24:0] were increased, correlating with sphingolipids, bile acids, and/or N-acetylated metabolites in plasma. Among proteins associated with CD, interleukin-24 correlated with plasma metabolites, including lactosyl-N-palmitoyl sphingosine [d18:1/16:0] and phosphatidyletanolamine [18:1/18:1], haemoglobin, and faecal calprotectin. In UC, interleukin-24, interleukin-17A, and C-C motif chemokine 11 correlated with several plasma metabolites, including N-acetyltryptophan, tryptophan, glycerate, and threonate, and with the Paediatric Ulcerative Colitis Activity Index, C-reactive protein, and faecal calprotectin.ConclusionsMucosal perturbations of lysophospholipids and sphingolipids characterised the metabolome in new-onset paediatric IBD and correlated with plasma metabolites. By integrating plasma metabolomics data with inflammatory proteins and clinical data, we identified clinical and inflammatory markers associated with metabolomic signatures for IBD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Prast-Nielsen, StefanieKarolinska Institutet
(författare)
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Correia, MarioUppsala universitet,Science for Life Laboratory, SciLifeLab,Analytisk kemi,Department of Chemistry - BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden(Swepub:uu)marco312
(författare)
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Globisch, DanielUppsala universitet,Science for Life Laboratory, SciLifeLab,Analytisk kemi,Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden; Department of Chemistry - BMC, Science for Life Laboratory, Uppsala University, Uppsala, Sweden(Swepub:uu)dangl308
(författare)
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Engstrand, LarsKarolinska Institutet
(författare)
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Schuppe-Koistinen, InaKarolinska Institutet
(författare)
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jshn
(författare)
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Uppsala universitetPediatrisk inflammations- och metabolismforskning samt barnhälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Crohn's & Colitis: Oxford University Press17:3, s. 418-4321873-99461876-4479
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