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Cerebrospinal fluid...
Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis
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Haroon, Humza (författare)
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Ho, Ada Man-Choi (författare)
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Gupta, Vinod K (författare)
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Dasari, Surendra (författare)
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- Sellgren, Carl M (författare)
- Karolinska Institutet
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- Cervenka, Simon (författare)
- Uppsala universitet,Psykiatri,Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden
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- Engberg, Göran (författare)
- Karolinska Institutet
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- Eren, Feride (författare)
- Karolinska Institutet
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- Erhardt, Sophie (författare)
- Karolinska Institutet
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Sung, Jaeyun (författare)
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Choi, Doo-Sup (författare)
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Journal of Psychiatric Research. - : Elsevier. - 0022-3956 .- 1879-1379. ; 171, s. 306-315
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Apart from their diagnostic, monitoring, or prognostic utility in clinical settings, molecular biomarkers may be instrumental in understanding the pathophysiology of psychiatric disorders, including schizophrenia. Using untargeted metabolomics, we recently identified eight cerebrospinal fluid (CSF) metabolites unique to first-episode psychosis (FEP) subjects compared to healthy controls (HC). In this study, we sought to investigate the CSF proteomic signatures associated with FEP. We employed 16-plex tandem mass tag (TMT) mass spectrometry (MS) to examine the relative protein abundance in CSF samples of 15 individuals diagnosed with FEP and 15 age-and-sex-matched healthy controls (HC). Multiple linear regression model (MLRM) identified 16 differentially abundant CSF proteins between FEP and HC at p < 0.01. Among them, the two most significant CSF proteins were collagen alpha-2 (IV) chain (COL4A2: standard mean difference [SMD] = -1.12, p = 1.64 × 10-4) and neuron-derived neurotrophic factor (NDNF: SMD = -1.03, p = 4.52 × 10-4) both of which were down-regulated in FEP subjects compared to HC. We also identified several potential CSF proteins associated with the pathophysiology and the symptom profile and severity in FEP subjects, including COL4A2, NDNF, hornerin (HRNR), contactin-6 (CNTN6), voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3), tropomyosin alpha-3 chain (TPM3 and TPM4). Moreover, several protein signatures were associated with cognitive performance. Although the results need replication, our exploratory study suggests that CSF protein signatures can be used to increase the understanding of the pathophysiology of psychosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Cerebrospinal fluid
- First-episode psychosis
- Proteomics
- Schizophrenia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Haroon, Humza
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Ho, Ada Man-Choi
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Gupta, Vinod K
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Dasari, Surendra
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Sellgren, Carl M
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Cervenka, Simon
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visa fler...
-
Engberg, Göran
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Eren, Feride
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Erhardt, Sophie
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Sung, Jaeyun
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Choi, Doo-Sup
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Journal of Psych ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet