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Sökning: onr:"swepub:oai:DiVA.org:uu-525075" > Bariatric Surgery I...

  • Barbosa, PedroUniv Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal. (författare)

Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • MDPI,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-525075
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525075URI
  • https://doi.org/10.3390/biom14020219DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Low-grade inflammation is closely linked to obesity and obesity-related comorbidities; therefore, immune cells have become an important topic in obesity research. Here, we performed a deep phenotypic characterization of circulating T cells in people with obesity, using flow cytometry. Forty-one individuals with obesity (OB) and clinical criteria for bariatric surgery were enrolled in this study. We identified and quantified 44 different circulating T cell subsets and assessed their activation status and the expression of immune-checkpoint molecules, immediately before (T1) and 7-18 months after (T2) the bariatric surgery. Twelve age- and sex-matched healthy individuals (nOB) were also recruited. The OB participants showed higher leukocyte counts and a higher percentage of neutrophils. The percentage of circulating Th1 cells were negatively correlated to HbA1c and insulin levels. OB Th1 cells displayed a higher activation status and lower PD-1 expression. The percentage of Th17 and Th1/17 cells were increased in OB, whereas the CD4+ Tregs' percentage was decreased. Interestingly, a higher proportion of OB CD4+ Tregs were polarized toward Th1- and Th1/17-like cells and expressed higher levels of CCR5. Bariatric surgery induced the recovery of CD4+ Treg cell levels and the expansion and activation of Tfh and B cells. Our results show alterations in the distribution and phenotype of circulating T cells from OB people, including activation markers and immune-checkpoint proteins, demonstrating that different metabolic profiles are associated to distinct immune profiles, and both are modulated by bariatric surgery.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Pinho, AryaneUniv Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal. (författare)
  • Lazaro, AndreCtr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal. (författare)
  • Paula, DiogoCtr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal. (författare)
  • Tralhao, Jose G.Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Univ Coimbra, Inst Biophys, Fac Med, P-3000548 Coimbra, Portugal. (författare)
  • Paiva, ArturUniv Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal.;Inst Politecn Coimbra, ESTESC Coimbra Hlth Sch, Ciencias Biomed Labs, P-3046854 Coimbra, Portugal. (författare)
  • Pereira, Maria J.,1981-Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)marpe927 (författare)
  • Carvalho, EugeniaUniv Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal. (författare)
  • Laranjeira, PaulaUniv Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal. (författare)
  • Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Biomolecules: MDPI14:22218-273X

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