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Older age of celiac...
Older age of celiac disease diagnosis and risk of autoimmune disease : A nationwide matched case-control study
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- Yuan, Shuai (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Leffler, Daniel (författare)
- Harvard Med Sch, Beth Israel Deaconess Med Ctr, Celiac Ctr, Boston, MA USA.
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- Lebwohl, Benjamin (författare)
- Columbia Univ, Med Ctr, Dept Med, Celiac Dis Ctr, New York, NY USA.
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- Green, Peter H. R. (författare)
- Columbia Univ, Dept Med & Surg Pathol, Coll Phys & Surg, New York, NY USA.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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- Söderling, Jonas (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Sun, Jiangwei (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Ludvigsson, Jonas F. (författare)
- Columbia Univ, Med Ctr, Dept Med, Celiac Dis Ctr, New York, NY USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Örebro Univ Hosp, Dept Pediat, Örebro, Sweden.
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Karolinska Institutet Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Journal of Autoimmunity. - : Elsevier. - 0896-8411 .- 1095-9157. ; 143
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ObjectivesCeliac disease (CeD) has been linked to an increased risk of other autoimmune diseases, yet the impact of delayed CeD diagnosis on risk of developing additional autoimmune diseases remains uncertain. We investigated this through a nationwide matched case-control study.MethodsUsing the ESPRESSO cohort with histophatology data from Sweden's 28 pathology departments, we assessed 46,575 biopsy-confirmed CeD cases from 1964 to 2017. We extracted 225,295 matched controls without histopathology information from the Swedish Total Population Register. Autoimmune disease was defined through diagnostic codes in the National Patient Register. Through conditional logistic regression we estimated odds ratio (OR) of autoimmune disease up until CeD diagnosis/matching date comparing CeD cases to controls across different age strata.ResultsA total of 3059 (6.6 %) CeD patients and 4076 (1.8 %) controls had earlier autoimmune disease. The overall OR for autoimmune disease in CeD was 3.50 (95%CI 3.32–3.70). The risk of autoimmune disease did not escalate with increasing age at CeD diagnosis. Compared with controls, the OR of autoimmune disease in CeD patients was 7.70 (95%CI 4.71–12.57) in those diagnosed with CeD in 0–4 years, 19.02 (95%CI 13.80–26.23) in 5–9 years, 6.18 (95%CI 5.14–7.44) in 10–14 years, 4.80 (95%CI 3.97–5.79) in 15–19 years, 4.24 (95%CI 3.55–5.07) in 20–29 years, 4.65 (95%CI 3.93–5.51) in 30–39 years, 3.67 (95%CI 3.30–4.09) in 40–59 years, and 1.67 (95%CI 1.50–1.85) in ≥60 years.ConclusionsThis study revealed an increased risk of autoimmune disease among CeD patients compared with controls. However, older age at CeD diagnosis did not seem to escalate the risk of autoimmune diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Autoimmune disease
- Case-control
- Celiac disease
- Delayed diagnosis
- Gluten exposure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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