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A model‐based appro...
A model‐based approach leveraging in vitro data to support dose selection from the outset : A framework for bispecific antibodies in immuno‐oncology
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- Sánchez, Javier (författare)
- Uppsala universitet,Institutionen för farmaci,Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland,Farmakokinetik och Farmakodynamik
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- Claus, Christina (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Zurich Schlieren Switzerland
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- Albrecht, Rosmarie (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Zurich Schlieren Switzerland
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- Gaillard, Brenda C. (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Zurich Schlieren Switzerland
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- Marinho, Joana (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Zurich Schlieren Switzerland
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- McIntyre, Christine (författare)
- Roche Pharma Research and Early Development Roche Innovation Center Welwyn Welwyn Garden City UK
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- Tanos, Tamara (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Basel Basel Switzerland
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- Boehnke, Axel (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Basel Basel Switzerland
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- Friberg, Lena E. (författare)
- Uppsala universitet,Institutionen för farmaci,Farmakokinetik och Farmakodynamik
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- Jönsson, Siv, 1963- (författare)
- Uppsala universitet,Institutionen för farmaci,Farmakometri
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- Frances, Nicolas (författare)
- Roche Pharma Research and Early Development (pRED) Roche Innovation Center Basel Basel Switzerland
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- Engelska.
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Ingår i: CPT. - : John Wiley & Sons. - 2163-8306. ; 12:11, s. 1804-1818
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- FAP-4-1BBL is a bispecific antibody exerting 4-1BB-associated T-cell activation only while simultaneously bound to the fibroblast activation protein (FAP) receptor, expressed on the surface of cancer-associated fibroblasts. The trimeric complex formed when FAP-4-1BBL is simultaneously bound to FAP and 4-1BB represents a promising mechanism to achieve tumor-specific 4-1BB stimulation. We integrated in vitro data with mathematical modeling to characterize the pharmacology of FAP-4-1BBL as a function of trimeric complex formation when combined with the T-cell engager cibisatamab. This relationship was used to prospectively predict a range of clinical doses where trimeric complex formation is expected to be at its maximum. Depending on the dosing schedule and FAP-4-1BBL plasma: tumor distribution, doses between 2 and 145 mg could lead to maximum trimeric complex formation in the clinic. Due to the expected variability in both pharmacokinetic and FAP expression in the patient population, we predict that detecting a clear dose-response relationship would remain difficult without a large number of patients per dose level, highlighting that mathematical modeling techniques based on in vitro data could aid dose selection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Farmaceutisk vetenskap
- Pharmaceutical Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Sánchez, Javier
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Claus, Christina
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Albrecht, Rosmar ...
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Gaillard, Brenda ...
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Marinho, Joana
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McIntyre, Christ ...
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visa fler...
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Tanos, Tamara
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Boehnke, Axel
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Friberg, Lena E.
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Jönsson, Siv, 19 ...
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Frances, Nicolas
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmaceutiska ve ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Cancer och onkol ...
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Uppsala universitet