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The enigma of scler...
The enigma of sclera-specific autoimmunity in scleritis
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- Vergouwen, Daphne P. C. (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands.
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- van Beek, Adriaan A. (författare)
- Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
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- de Hoog, Joeri (författare)
- Dept Ophthalmol, Amsterdam UMC, Amsterdam, Netherlands.
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- de Boer, Joke H. (författare)
- Dept Ophthalmol, UMC Utrecht, Utrecht, Netherlands.
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- Los, Leonoor I. (författare)
- Dept Ophthalmol, UMC Groningen, Groningen, Netherlands.
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- Gijs, Marlies (författare)
- Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands.
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- Erckens, Roel J. (författare)
- Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands.
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- Verdijk, Rob M. (författare)
- Univ Med Ctr Rotterdam, Dept Pathol, Erasmus MC, Rotterdam, Netherlands.
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- Haasnoot, Geert W. (författare)
- Leiden Univ Med Ctr, Eurotransplant Reference Lab, Leiden, Netherlands.
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- Roelen, Dave L. (författare)
- Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
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- Rothova, Aniki (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
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- Rönnelid, Johan (författare)
- Uppsala universitet,Vaskulärbiologi
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- Berge, Josianne C. Ten (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
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- Schreurs, Marco W. J. (författare)
- Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.
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Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands. Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Journal of Autoimmunity. - : Elsevier. - 0896-8411 .- 1095-9157. ; 144
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Scleritis
- Autoimmunity
- Autoantibodies
- Type II collagen antibodies
- HLA-Association
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Vergouwen, Daphn ...
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van Beek, Adriaa ...
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de Hoog, Joeri
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de Boer, Joke H.
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Los, Leonoor I.
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Gijs, Marlies
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visa fler...
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Erckens, Roel J.
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Verdijk, Rob M.
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Haasnoot, Geert ...
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Roelen, Dave L.
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Rothova, Aniki
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Rönnelid, Johan
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Berge, Josianne ...
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Schreurs, Marco ...
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visa färre...
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Uppsala universitet