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Importance of resec...
Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy : population-based cohort study
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- Ostrand, Emil (författare)
- Skane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
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- Rystedt, Jenny (författare)
- Skane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
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- Engstrand, Jennie (författare)
- Karolinska Univ Hosp, Div Surg, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.
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- Frühling, Petter (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Akad Univ Hosp, Sweden; Uppsala Univ, Sweden,Akad Univ Hosp, Dept Surg, Uppsala, Sweden.
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- Hemmingsson, Oskar (författare)
- Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Sandström, Per (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ Hosp, Dept Surg, Linköping, Sweden.;Linköping Univ, Dept Clin & Expt Med Sci, Linköping, Sweden.
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- Eilard, Malin Sternby (författare)
- Sahlgrens Univ Hosp, Dept Transplantat & Liver Surg, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Clin Sci, Gothenburg, Sweden.
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- Tingstedt, Bobby (författare)
- Skane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
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- Buchwald, Pamela (författare)
- Skane Univ Hosp, Dept Surg, Malmö, Sweden.;Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.
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Skane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden;Lund Univ, Dept Clin Sci Lund, Lund, Sweden. Karolinska Univ Hosp, Div Surg, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden. (creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: BJS Open. - : Oxford University Press. - 2474-9842. ; 8:3
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and >= 1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. Methods Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model. Results A total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin <1 mm. The overall survival in patients with a margin of 0 mm or 0.1-0.9 mm was 42 (95% c.i. 31 to 53) and 48 (95% c.i. 35 to 62) months respectively, compared with 75 (95% c.i. 65 to 85) for patients with >= 1 mm margin, P < 0.001. Margins of 0 mm or 0.1-0.9 mm were associated with poor overall survival in the multivariable analysis, HR 1.413 (95% c.i. 1.030 to 1.939), P = 0.032, and 1.399 (95% c.i. 1.025 to 1.910), P = 0.034, respectively. Conclusions Despite modern chemotherapy the resection margin is still an important factor for the survival of patients resected for colorectal liver metastasis, and a margin of >= 1 mm is needed to achieve the best possible outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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