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Sökning: onr:"swepub:oai:DiVA.org:uu-528222" > Importance of resec...

  • Östrand, EmilLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Surgery, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden (författare)

Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy : population-based cohort study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-528222
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528222URI
  • https://doi.org/10.1093/bjsopen/zrae035DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203564URI
  • https://lup.lub.lu.se/record/e18aa592-10f8-4709-9f8f-ba15491d25b8URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224927URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:157261489URI
  • https://gup.ub.gu.se/publication/338861URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Erik och Angelica Sparres forskningsstiftelse (EO)
  • Background Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and >= 1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. Methods Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model. Results A total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin <1 mm. The overall survival in patients with a margin of 0 mm or 0.1-0.9 mm was 42 (95% c.i. 31 to 53) and 48 (95% c.i. 35 to 62) months respectively, compared with 75 (95% c.i. 65 to 85) for patients with >= 1 mm margin, P < 0.001. Margins of 0 mm or 0.1-0.9 mm were associated with poor overall survival in the multivariable analysis, HR 1.413 (95% c.i. 1.030 to 1.939), P = 0.032, and 1.399 (95% c.i. 1.025 to 1.910), P = 0.034, respectively. Conclusions Despite modern chemotherapy the resection margin is still an important factor for the survival of patients resected for colorectal liver metastasis, and a margin of >= 1 mm is needed to achieve the best possible outcome.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rystedt, JennyLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Surgery,Lund University Research Groups,Department of Surgery, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden(Swepub:lu)med-jlk (författare)
  • Engstrand, JennieKarolinska Institute,Division of Surgery, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden (författare)
  • Frühling, PetterUppsala University,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Akad Univ Hosp, Sweden; Uppsala Univ, Sweden,Akad Univ Hosp, Dept Surg, Uppsala, Sweden.,Department of Surgery, Akademiska University Hospital, Uppsala, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)petfr508 (författare)
  • Hemmingsson, Oskar,1975-Umeå universitet,Umeå University,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)osrhen96 (författare)
  • Sandström, PerLinköping University,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ Hosp, Dept Surg, Linköping, Sweden.;Linköping Univ, Dept Clin & Expt Med Sci, Linköping, Sweden.,Department of Surgery, Linköping University Hospital, Linköping, Sweden; Department of Clinical and Experimental Medicine Sciences, Linköping University, Linköping, Sweden(Swepub:liu)persa07 (författare)
  • Sternby Eilard, Malin,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xstema (författare)
  • Tingstedt, BobbyLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Surgery, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden(Swepub:lu)kir-bti (författare)
  • Buchwald, PamelaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Surgery, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences Malmö, Lund University, Lund, Sweden(Swepub:lu)med-pbc (författare)
  • Kirurgi, LundSektion V (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BJS Open: Oxford University Press8:32474-9842

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