Sökning: onr:"swepub:oai:DiVA.org:uu-530811" >
Associations betwee...
Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals.
-
- Xue, Pei (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
Merikanto, Ilona (författare)
-
Delale, Eva A (författare)
-
visa fler...
-
Bjelajac, Adrijana (författare)
-
Yordanova, Juliana (författare)
-
Chan, Rachel N Y (författare)
-
Korman, Maria (författare)
-
Mota-Rolim, Sérgio A (författare)
-
Landtblom, Anne-Marie (författare)
-
Matsui, Kentaro (författare)
-
Reis, Catia (författare)
-
Penzel, Thomas (författare)
-
Inoue, Yuichi (författare)
-
Nadorff, Michael R (författare)
-
Holzinger, Brigitte (författare)
-
Morin, Charles M (författare)
-
Espie, Colin A (författare)
-
Plazzi, Giuseppe (författare)
-
De Gennaro, Luigi (författare)
-
Chung, Frances (författare)
-
Bjorvatn, Bjørn (författare)
-
Wing, Yun Kwok (författare)
-
Dauvilliers, Yves (författare)
-
Partinen, Markku (författare)
-
- Benedict, Christian, Docent, 1976- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: International Journal of Obesity. - 0307-0565 .- 1476-5497.
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep's critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential.METHODS: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires.RESULTS: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found.CONCLUSIONS: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Xue, Pei
-
Merikanto, Ilona
-
Delale, Eva A
-
Bjelajac, Adrija ...
-
Yordanova, Julia ...
-
Chan, Rachel N Y
-
visa fler...
-
Korman, Maria
-
Mota-Rolim, Sérg ...
-
Landtblom, Anne- ...
-
Matsui, Kentaro
-
Reis, Catia
-
Penzel, Thomas
-
Inoue, Yuichi
-
Nadorff, Michael ...
-
Holzinger, Brigi ...
-
Morin, Charles M
-
Espie, Colin A
-
Plazzi, Giuseppe
-
De Gennaro, Luig ...
-
Chung, Frances
-
Bjorvatn, Bjørn
-
Wing, Yun Kwok
-
Dauvilliers, Yve ...
-
Partinen, Markku
-
Benedict, Christ ...
-
visa färre...
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Uppsala universitet