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Associations Between Blood Levels of NLRP3 Inflammasome Components and Obsessive Compulsive Disorder
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- Tetik, Melike (författare)
- Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.
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- Direk, Nese (författare)
- Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.
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- Uzgan, Betul Onder (författare)
- Canakkale Onsekiz Mart Univ, Dept Biol, Canakkale, Turkiye.
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- Aykac, Cansu (författare)
- Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.
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- Ekinci, Burcu (författare)
- Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.
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- Yaras, Tutku (författare)
- Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.
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- Kuruoglu, Aykut (författare)
- Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.
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- Özel, Fatih (författare)
- Uppsala universitet,Fysiologi och miljötoxikologi
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- Ermis, Cagatay (författare)
- Dokuz Eylul Univ, Fac Med, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
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- Alkin, Tunc (författare)
- Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye.
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- Oktay, Yavuz (författare)
- Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Med Biol, Izmir, Turkiye.
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Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye. (creator_code:org_t)
- Turk Noropsikiyatri Dernegi, 2023
- 2023
- Engelska.
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Ingår i: Nöropsikiyatri Arşivi. - : Turk Noropsikiyatri Dernegi. - 1300-0667. ; 60:1, s. 28-36
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
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- Introduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regarding the underlying mechanisms are yet to be revealed. The NLRP3 inflammasome complex is an important component of the innate immune system that initiates and mediates inflammatory response to a variety of stimuli. This study aims to inquire into a possible association between NLRP3 inflammasome complex and OCD. Methods: This case-control study included 103 participants (51 cases with OCD and 52 healthy controls). All participants were evaluated with the Yale Brown Obsessive Compulsive Scale, Hamilton Depression Scale, and Hewitt Multidimensional Perfectionism Scale. RNA and proteins were extracted from peripheral blood mononuclear cells. Expression of NLRP3 inflammasome components were determined using quantitative real-time polymerase chain reaction (PCR) and Western blotting. Levels of Serum IL-1beta and IL-18 cytokine were determined by ELISA. Results: NEK7 and CASP1 mRNA levels were significantly higher in OCD patients, compared to controls. Pro-caspase-1 protein levels were elevated, as well. Regression analysis showed that NEK7 mRNA and procaspase-1 protein levels can differentiate OCD and healthy control groups. Conclusion: Our results provide insight into the molecular alterations that could explain the inflammation-OCD association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- ASC
- caspase-1
- inflammasome
- NEK7
- NLRP3
- obsessive-compulsive disorder
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tetik, Melike
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Direk, Nese
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Uzgan, Betul Ond ...
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Aykac, Cansu
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Ekinci, Burcu
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Yaras, Tutku
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Kuruoglu, Aykut
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Özel, Fatih
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Ermis, Cagatay
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Alkin, Tunc
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Oktay, Yavuz
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